UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 3 / Published : 2014-01

Order : 2, and page :208 - 215

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Original Article :

Effect of infusum kopi leaves (coffea robusta lindl.) on blood glucose level on the mice in alloxan induced

Author :

  1. Sri Purwaningsih*1
  1. Fakultas Kedokteran Unair

Abstract :

This experiment is conducted in order to prove the theory that the infusum of bay leaf (Coffea Robusta) may lower the blood glucose level of the sample rat which was afflicted with Diabetes Mellitus (DM). Thirty mice samples (Mus musculus) were divided into 5 groups, with each groups consisted of 6 mices samples. Those groups are: control group, using normal rats (not afflicted with DM) which were only given aquades of 1 ml/oral/samples, while 24 mices samples were afflicted diabetes melitus by injecting 140 mg/kg body weight of aloxan through intra peritoneal route. On the two day after the aloxan was administered, those mices became afflicted with DM, which is proven with the rise of the blood glucose level of >200mg/dl. The group which was given the treatment, the treatment 0 (control negative) were the DM mices which were only given aquades 0,1 ml/oral/day, treatment group 1 (P1) were the DM mices which were given 5% bay leaves Coffea Robusta infusion/oral/day, treatment group 2 (P2) were the DM mices which were given 10% leaves Coffea Robusta infusion/oral/day, treatment group 3 (P3) were the DM mices which were given 20% bay leaves Coffea Robusta infusum/oral/day and treatment group 4 (control positive) were the DM mices which were given glibenclamid 0,65 mg/ body weight/oral/day. All samples were given the same method of treatment, by giving the dosage once daily for a period of 14 days. The observed parameter was the blood glucose level measurement from 0 hour, 1st hour, 2nd hour, day 7th, day 14th after the treatment was given. The data obtained was analysed using Anava. The result from giving the dosage of 5% of bay leaves infusion Coffe robusta was the decrease in the blood glucose level of the rats on the 7 th day, and the blood glucose level returned to normal on the 14 th day, while giving the dosage of 10% and 20% oral/day of bay leaves infusion Coffe robusta resulted in the normalization of the blood glucose level on the 7th day, and the blood glucose dropped below normal on the 14th day.

Keyword :

Infusum, Coffea Robusta Lindl Ex De wild, Aloksan, Mice afflicted with DM, Blood glucose,


References :

Shenoy C,(2000) Hypoglycemic activity of Green–tea in mice . : Indian J Exp Biol. 38(3): 278-9

Szkuldelski T,(2001) The Mechanism of Alloxan and Streptozotocin Action in B Cells of the Rat Pancreas . : Physiol Res. 50: 536-546

Tjokroprawiro A.,(2001) Diabetes in: Focus on Oxidative Stress in Diabetes Mellitus Surabaya : Diabetes Up Date X. 105-120





Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2014-11
  1. The Accuracy Of Production Equine Chorionic Gonadotropin (ecg) Frozen Dry From Local Horse For Increasing The Time Onset Of Oestrus In Madura Cattle
  2. Effect Of Infusum Kopi Leaves (coffea Robusta Lindl.) On Blood Glucose Level On The Mice In Alloxan Induced
  3. Comparison Of Sperm Quality After Separation X And Y Chromosome Between Column Albumin Method And Electric Separating Sperm (ess) Method On Ekor Gemuk Sheep
  4. Potential Of Vitamin E On Spermatogenic Cell Number In Mice Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  5. The Comparison Of Maturation Between Bovine Oocyte Vitrification Before And After In Vitro Maturation
  6. Potency Of Pediococcus Pentosaceus Protease On Meat Tenderness And Histological
  7. Effect Of Vitamin E On Decreased Of The Leydig Cell Necrosis Number In Mice Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  8. The Immunomodulator Potency Of Combination Of Andrographis Paniculata And Echinacea Purpurea On Total And Differential Leucocytes Count In Mice With Heat Stress
  9. The Effect Of Various Egg Duck Concentration In Skim Milk As Semen Diluters Of Fat-tailed Sheep For Motility, Viability And Intact Plasma Membrane Spermatozoa Before Freezing
  10. Antibacterial Effect Of Mango’s Leaves (mangifera Indica) Extract Against Staphylococcus Aureus And Escherichia Coli
  11. Effectiveness Of Honey And The Juice Of Noni (morinda Citrifolia Linn) As Well As Mixtures Of The Number Of Bacteria On Chicken Carcasses
  12. The Potential Of Soursop (annona Muricata Linn.) Leaves Extract As Immunostimulantin Rabbit Pbmc
  13. Crude Protein And Crude Fiber In Rice Bran Fermented By Acidothermus Cellulolyticus Or Aspergillus Terreus Wpl 109 Or Wpl 209
  14. Level Of Contamination Of Salmonella Sp In White Prawns (litopenaeus Vannamei) Sold At Some Wet And Modern Market In Surabaya
  15. Potensi Alkaloid Achyranthes Aspera Linn Terhadap Ekspresi Protein Bax Sel Kanker Payudara Pada Mencit (mus Musculus) Yang Diinduksi Benzopyrene

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