UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 1 / No. 3 / Published : 2008-11

Order : 1, and page :79 - 82

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Original Article :

Effect of justicia gendarussa burm.f. leaves water fraction on male rabbit liver and renal fuction(sub acute toxicity test of justicia gendarussa burm.f. leaves water fraction as male contraceptive agent)

Author :

  1. Bambang Prajogo E.W.*1
  2. Farida Ifadotunnikmah*2
  3. Alifia Putri Febriyanti*3
  4. Jusak N*4
  1. Fakultas Farmasi Universitas Airlangga
  2. Fakultas Farmasi Universitas Airlangga
  3. Fakultas Farmasi Universitas Airlangga
  4. Fakultas Kedokteran Universitas Airlangga

Abstract :

Justicia gendarussa Burm. f. leaves was found to be traditionally used as male contraceptive agent by several ethnic groups in central part of Papua, Indonesia. Previous study showed that J. gendarussa could inhibit mice spermatozoa penetration onto mice ovum. It was found that J. gendarussa could be developed as contraceptive medicine. Hence, it is necessary to conduct research on its toxicity. One of the premedical researches which have carried on this research was subacute toxicity test.The aim of this research was to observe the influence of water fraction of J. gendarussa leaves on rabbit’s liver and kidney functions. The parameters used on this research were SGOT, SGPT, Alkaline phosphatase, Blood Urea Level, and creatinine level. Research was carried out by administrating the treatment groups with oral preparation of of J. gendarussa leaves water fraction once daily for 45 days (1,5 times of rabbit spermatogenesis cycle). The doses of J. gendarussa water fraction for each treatment groups were 579,48; 482,90 and 340,87 mg/kg BW. Rabbit serum samples were collected and measured by Automatic Hitachi Analyzer 902. Data then were analyzed by paired t test. Result showed that J. gendarussa leaves in the three doses did not influence rabbit’s liver and kidney functions.

Keyword :

Justicia gendarussa Burm. f., Sub acute toxicity test, Liver and Renal Function, Rabbit, .,


References :

Chakravarty, A.K.,dan P.P.G. Dastidar,(1982) Simple Aromatic Amines From Justicia Gendarussa 13 C NMR Spectra of The Bases and Their Analogues . : Tetrahedron

Derelanko, J. Michael ., and A.Hollinger Manfred,(1995) CRC Handbook of Toxicology USA : CRC Press Inc.





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Volume : 1 / No. : 3 / Pub. : 2008-11
  1. Effect Of Justicia Gendarussa Burm.f. Leaves Water Fraction On Male Rabbit Liver And Renal Fuction(sub Acute Toxicity Test Of Justicia Gendarussa Burm.f. Leaves Water Fraction As Male Contraceptive Agent)
  2. Isolation And Identification Of Staphylococcus Aureus Isolates From Milk Of Bovine Mastitis
  3. The Comparison Between Protein A Expression Of Staphylococcus Aureus And Coagulase Negative Staphylococci (cns) From Bovine Mastitis Milk
  4. Histopatology And Proliferation Activity Of Gland Mammae After Gift Curcuma Zedoaria Extract Which Dmba (dimethylbenz(a)antrasen) Initiation On Sprague Dawley Rat
  5. Lactoferrin Effect On Symptom And Body Weight In Short Bowel Syndrome
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  7. Toxoplasma Gondii Congenital Dissemination Number On Infected Pregnant Mice By Local Isolate On Difference Gestation Olds
  8. Reactivity Of Brucella Abortus Strain 19 Outer Membrane Protein Toward Polyclonal Antibody Anti Brucella Abortus Strain 19
  9. The Potency Of Sex Pheromone (z)-9-tricosene Female Housefly To Control Musca Dometica
  10. The Increasing Of Rice Straw Quality By Addtion Cellulolityc Bacteria Produce Microbe Of Rumen
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  13. The Usefull Of Mahkota Dewa Fruit (phaleria Macrocarpa) Extract As A Hepatotoxicity Prevention To Mice Caused By Induction Of Carbon Tetrachloride
  14. Yogurt Supplementation Study Of Rat (rattus Norvegicus) That Exposured By Formaldehyde Through Feeding Diet On Antioxidant Activity, Oxidative Damages Of Hepar Tissue