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Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 2 / Published : 2016-07

TOC : 9, and page :147 - 152

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Original Article :

Effect of red fruit (pandanus conoideus lam.) oil to litter size and congenital defecton lead intoxicated pregnant mice (mus musculus)

Author :

  1. Ronal Toga Sibarani*1
  2. Sri Pantja Madyawati*2
  3. Widjiati*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Intoxication of lead during pregnancy can increase the levels of Reactive Oxygen Species(ROS) that disrupts the physiological maternal pregnancy and embryonic development. Red fruit(Pandanus conoideus Lam.) was able to reduce levels of ROS because it contains carotenoidsand tocopherols which act as antioxidants. The purpose of this study was to find out the influenceof red fruit oil to increase litter size and decreased incidence of congenital defects in lead inducedpregnant mice. Mice were grouped into five groups, those are negative control, postive controlthat was induced by lead 0,011 mg/20 g BW orally as well as P1, P2, P3 that were induced bylead 0,011 mg/20 g BW and red fruit oil dose of 12 mg/kg BW, 24 mg/kg BW, 48 mg/kg BW.Results of this study were analyzed using ANOVA and Duncan test. The results showed a higherlitter size and congenital defects lower in lead induced pregnant mice with red fruit oil comparedto the positive control. The conclusion of this study is red fruit oil can increase litter size anddecrease the incidence of congenital defects in lead induced pregnant mice through an atioxidantmechanism.

Keyword :

Pandanus conoideus Lam., litter size, congenital defects, lead induced, ROS,

References :

  1. Al-Ani, I.M., I.N. Al-Khfaji, M.B. Fakhrildin, H.H. Mangalo and S.R. Al-Obaidi, (2009). The Effect of Lead Exposure of Mice during Pregnancy on The Morphology of Epididymal and Testicular Spermatozoa of Their Offspring. 8 (1):11-16 : J. Med. Int.
  2. Brandini, D.A., M.A. Sala and R.A. Lopes, (2011). Effects of Maternal Pb2+ Poisoning during Pregnancy on the Development of the Jaw (Meckel’s Cartilage) of Rat Fetus. 15 (1):17 – 19 : J. Appl. Sci. Environ. Manage.
  3. Chunmei, L., J.M. Yon, A.Y. Jung, J.G. Lee, K.Y. Jung, B.J. Lee, Y.W. Yun and S.Y. Nam., (2013). Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine. 2013:1-11 : Evid. B. Comp. and Alt. Med.


Archive Article

Cover Media Content

Volume : 9 / No. : 2 / Pub. : 2016-07
  1. Therapy effect of (pandanus conoideus inn) on female mice (mus musculus) infertility model toward the folicle diameter size of pre antral and antral histopathological features
  2. The effects of insulin transferin selenium supplementation on mice (mus musculus) embryos vitrification media at morula stage towards the viability of blastomere cells using fluorescence techniques after warming
  3. Staphylococcus aureus contamination rate on beef slaughter results in pegirian surabaya slaughterhouse
  4. Response of antibodies formed as result of brucella suis infection in mice (mus musculus) with complement fixation test (cft)
  5. Therapeutic effect of spirulinaplatensis extract on histopathological appearance of ethanol induced liver injury in rat (rattus norvegicus)
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  9. Utilization of coconut shell liquid smoke as preservation in chicken intestine on the value of total plate count
  10. Effect of red fruit (pandanus conoideus lam.) oil to litter size and congenital defecton lead intoxicated pregnant mice (mus musculus)
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