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Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 1 / Published : 2017-02

TOC : 13, and page :93 - 100

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Original Article :

Effect of rosella flower (hibiscus sabdariffa l.) extract on liver histhopathologic of male mice (mus musculus) exposed plumbum acetate

Author :

  1. Boginskaya Letsoin*1
  2. Pudji Srianto*2
  3. Rochmah Kurnijasanti*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The research aims was to study the histological change of mice’s (Mus musculus)liver that were given the extract of rosella (Hibiscus sabdariffa L.) and were exposedto Plumbum acetate per oral. It was used 25 male mice (Mus musculus) as the samplethat were divided into five groups by simple random sampling. Group Control negativeof the control was given CMC – Na and aquadest, Group Control positive were given20 mg Plumbum acetate, Group P1, P2 and P3 were given 200 mg, 400 mg, 800 mg ofrosella (Hibiscus sabdariffa L.) extract and 20 mg Plumbum acetate. The treatment wasgiven during 21 days by giving Plumbum acetate once in a hour after giving the extract.On the 29th day, all of the mice (Mus musculus) were necropsied then the liver was takenand processed by Hematoxylin eosin staining method. The examination of histologicalchange was conducted based on the necrosies, degeneration, activated ku:ppfer cell andsinusoidal dilatation. The result of statistical analysis using Kruskal Wallis and Mann –Whitney Test. It was concluded that the rosella (Hibiscus sabdariffa L.) extract with dosecould influence on the liver damage which was exposed with Plumbum acetate per oral.

Keyword :

rosella (Hibiscus sabdariffa Linn.), mice (Mus musculus), plumbum acetate (Pb asetat), histopatologi, liver,

References :

  1. Daniel, W.W. , (1991). Statistik Non Parametrik Terapan. Alih Bahasa : Ale Tri Kantjono. . 272-275. : Penerbit PT. Gramedia. Jakarta.
  2. Ercal, N., H. Gurer. and N. Aykin-Burns. , (2001). Toxic Metals and Oxidative Stress. Part 1. Mechanisms Involved in Metal Induced Oxidative Damage. . 1:529-539. : Current Topics Medicinal Chemistry.
  3. Gurer, H. and N. Ercal. , (2000). Can Antioxidants be Beneficial in The Treatment of Lead Poisoning.. 29 (10): 927-945. : Free Radical Biology and Medicine.


Archive Article

Cover Media Content

Volume : 10 / No. : 1 / Pub. : 2017-02
  1. Isolation and identification vibrio sp as vibriosis cause of agent at grouper fish (epinephelus fuscoguttatus) in banyuwangi regency
  2. Identification of species and stage of mite causes scabies by crusting severity on the rabbits
  3. Potency of curcumin on histopathological changes in the kidney of pregnant mice (mus musculus) exposed to cadmium
  4. Effect of vitamin c and e towards histopathological changes of duodenum in mice induced with borax
  5. The effects of crude protein bovine seminal plasma addition in skim milk and egg yolk diluent to motility, viability, dna fragmentation, and necrosis of ram spermatozoa after equilibration
  6. The effect of red fruit oil (pandanus conoideus lam.) on histopathology of follicle development in infertile mice modelling
  7. Prevalence and infection level of gastrointestinal worm nematode on long tailed macaque (macaca fascicularis) at taman wisata wendit malang regency
  8. Prevalence of distomatosis on various type of slaughtered cattle at penggaron semarang abattoir
  9. Pattern of antibiotics resistance on escherichia coli that isolated from raw milk in surabaya
  10. Effect of mangosteen (garcinia mangostana linn.) pericarp extracts on the diameter of mice (mus musculus) pre antral and antral follicles
  11. Semen quality, hsp 70 expression and dna damage of post thawing limousine bull spermatozoa after cooled at 5 °c
  12. The effects of propolis on histological liver in male mice (mus musculus)
  13. Effect of rosella flower (hibiscus sabdariffa l.) extract on liver histhopathologic of male mice (mus musculus) exposed plumbum acetate
  14. Effect of electrical field on the death of staphylococcus aures in milk
  15. The effect of mimosa pudica root extract to histopathological representation of rattus norvegicus liver injected with naja sputatrix venom
  16. Androgen dihydrotestosterone and its role in male reproductive system