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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 2 / Published : 2014-07

TOC : 12, and page :172 - 177

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Original Article :

Effect of sambiloto leaf extract (andrographis paniculata ness) to histopathological pancreatic langerhans islet cells on rats (rattus norvegicus) with cystic ovary model

Author :

  1. Portia Sumarsono*1
  2. Widjiati*2
  3. Sri Pantja Madyawati*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Polycystic Ovary Sindrome (PCOS) or cystic ovary is a disease of endocrine system, which is follicles on the surface were never ovulated and androgen levels in the body increased. Sambiloto leaf extract (Andrographis paniculata Ness) can stimulate the release of insulin and increase the effectiveness of insulin receptors so that no insulin resistance. The purpose of this research was to know the influence of sambiloto on decreasing the number of cells in pancreatic islets of Langerhans in rat model of cystic ovaries with insulin resistance. The rats were grouped into five groups, that are a negative control, positive control with testosterone injection 1 mg/kgBW during 28 days, P1 with testosterone injection 1 mg/kgBW during 28 days and extract of sambiloto with the dose 18 mg/kgBW, P2 36 mg/kgBW, and P3 72 mg/kgBW respectively during 21 days. The results of this research were analyzed using ANOVA and Duncan test. The results showed that the number of Langerhans islet cells decrease in compliance with increasing dose of sambiloto leaf extract. The conclusion of this research is sambiloto leaf extract can decrease the number of cells in the pancreatic islets of Langerhans on rats model of cystic ovary through improvement of insulin sensibility.

Keyword :

Andrographis paniculata Ness, PCOS, Insulin resistance, Islet of Langerhans,

References :

  1. Aryani, H.P, (2013). Perubahan Kadar Insulin dan Gambaran Perkembangan Folikel Tikus (Rattus norvegicus) Model SOPK Dengan Resistensi Insulin yang Diterapi Ekstrak Daun Sambiloto (Andrographis paniculata). Surabaya : [Thesis]. Fakultas Kedokteran. Universitas Airlangga
  2. Cibula D., R. Cifkova and M. Fanta M., (2000). Increased risk of non-insulin dependent diabetes mellitus, arterial hypertension and coronary artery disease in perimenopausal women with a history of the polycystic ovary syndrome.. . : Hum Repro. 15(4): 785-789.
  3. Hidayah, R., (2008). Pengaruh Lama Pemberian Ekstrak Daun Sambiloto (Andrographis paniculata Ness.) Terhadap Glukosa Darah dan Gambaran Histologi Pankreas Tikus (Rattus norvegicus) Diabetes. Surabaya : [Skripsi]. Fakultas Sains dan Teknologi Universitas Islam Negeri Malang


Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2014-07
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  12. Effect of sambiloto leaf extract (andrographis paniculata ness) to histopathological pancreatic langerhans islet cells on rats (rattus norvegicus) with cystic ovary model
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