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Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 2 / Published : 2014-07

TOC : 15, and page :194 - 199

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Original Article :

Effect of vitamin e (α–tocopherol) on the number of leydig cell in mice treated with 2,3,7,8–tetrachlorodibenzo-p-dioxin (tcdd)

Author :

  1. Nuril Lisa Ramania*1
  2. Ajik Azmijah*2
  3. Wurlina*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The goal of this research was to verify the effect of vitamin E (α–tocopherol) on the number of Leydig cell in mice treated with 2,3,7,8–tetrachlorodibenzo-p-dioxin (TCDD). Five experimental groups of a combination of TCDD and vitamin E were designed as follows: 0 ng/kg/d and 0 mg/kg/d (P0), 100 ng/kg/d and 0 mg/kg/d (P1), 100 ng/kg/d and 11 mg/kg/d (P2), 100 ng/kg/d and 20 mg/kg/d (P3), and 100 ng/kg/d and 37 mg/kg/d (P4) respectively. Vitamin E and TCDD were given by oral gavage for 9 days. The results demonstrated that 2,3,7,8–tetrachlorodibenzo-p-dioxin (TCDD) could have any effect on male germ cells especially Leydig cell. TCDD decreased the number of Leydig cell in intertitial seminiferous tubule. Vitamin E (α–tocopherol), which is knownly well to have potential as an antioxidant, to protect the demage to the body caused by exposure to 2,3,7,8–tetrachlorodibenzo-p-dioxin (TCDD). Best dose of vitamin E is 37 mg/kg/d increased the number of Leydig cell as well as negative control.

Keyword :

Vitamin E, Leydig Number Cell, 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin,

References :

  1. Fujimaki, H.K. Nohara and T. Kobayashi, (2002). Effect of a single oral dose of 2,3,7,8 tetrachlorodibenzo-p-dioxin on immune function in male NC/Nga mice. . : Toxicology Science. 66(1) : 117-124
  2. Hariyatmi, (2004). Kemampuan Vitamin E Sebagai Antioksidan Terhadap Radikal Bebas Pada Usia Lanjut. . : MIPA. 14 (1) : 54
  3. Latchoumycandane, C. and P.P. Mathur, (2002). Effects of vitamin E on reactive oxygen species-mediated 2,3,7,8,tetrachlorodibenzo-p-dioxin toxicity in rat testis. . : Applied toxicology. 22(5) : 113-118


Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2014-07
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  2. Antibacterial activity of the supernatant of soil isolate bacillus subtilis against aeromonas hydrophila and staphylococcus aureus (in vitro)
  3. The potential of giving synbiotic in different ages of female broilers on histological of ileum
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  14. Cloning gene fragments non-structural 1 (ns1) of dengue virus subtype 1 (denv-1) as a material candidate of vaccine chimera
  15. Effect of vitamin e (α–tocopherol) on the number of leydig cell in mice treated with 2,3,7,8–tetrachlorodibenzo-p-dioxin (tcdd)