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Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 3 / Published : 2016-11

TOC : 2, and page :7 - 13

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Original Article :

Effect of vitamin e and vitamin c combination as preventive measure on the leydig cell number in mice (mus musculus) treated with borax

Author :

  1. Citra Ayu Pramesti*1
  2. Arimbi*2
  3. Pudji Srianto*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this research was to investigate the effect of vitamin E and Ccombination as preventive measure on Leydig cells number in mice (Mus musculus)treated with borax. Twenty five male micesof BALB/c strain divided into five groups; P1(vitamin control) was given 28 mg/Kg /day of vitamin C solution combinated 105 mg/Kg/day of vitamin E solution, P2 (borax control) was given 260 mg/Kg/day of borax,P3 was given combination of 28 mg/Kg/day vitamin C and 105 mg/Kg/day vitamin Esolutions and 260 mg/Kg/ day of boraks, P4 was given combination of 56 mg/Kg /dayof vitamin C and 210 mg/Kg/day of vitamin E solutions and 260 mg/Kg/day of borax, P5was given combination of 112 mg/Kg/day of vitamin C and 420 mg/Kg/day of vitaminE solutions and 260 mg/Kg/day of borax. Borax solution on P3, P4 and P5 groups treatedin an hour after each groups treated with combination of vitamin C and E solutions.The treatment were given by oral gavage for 14 days. The result indicated there was asignificant difference (P< 0.05) between P1 (vitamin control) and P2 (boraks control)group. Significant difference also shown on P2 (boraks control) with P3, P4, P5 groups.There was indicated that combination of vitamin C and vitamin E increased the numberof normal Leydig cell of mice (Mus musculus) treated with borax.

Keyword :

Vitamin E, Vitamin C, Leydig cell, mice, borax,

References :

  1. Chapin, R.E and Ku, W.W. , (1994). Mechanism of the Testicular Toxicity of Boric Acid in Rats: . 102(7): 89- 101. : In Vivo and In Vitro Studies.
  2. Cox, R.R., and Kamprath, E. J. Eds. J J Mortvedt, P M Giordano and W L Lindsay., (2004). Essential Micronutrient Soil Test. In Micronutrients in Agriculture. . Pp 289-317. : Soil Science Soc. Amer., Madison.
  3. Creasy, D.M. , (2001). Pathogenesis of Male reproductive Toxicity. . Vol 29. 1:64-76. : Toxicologic Pathology,


Archive Article

Cover Media Content

Volume : 9 / No. : 3 / Pub. : 2016-11
  1. The effect of spirulina platensis extract immersion as immunostimulant to intestine histopathology of aeromonas hydrophila infected gouramy (osphronemus gouramy)
  2. Effect of vitamin e and vitamin c combination as preventive measure on the leydig cell number in mice (mus musculus) treated with borax
  3. The influence of beta carotene to live fetus percentage in mice (mus musculus) that exposured by cigarette smoke
  4. Effects of vitamin c and vitamin e combinationas prevention on the liver histopathological in mice (mus musculus) treated with borax
  5. Effect of moringa oleifera leaf extract on the percentage of necrotic purkinje cells in mice (mus musculus) induced by methylmercury