Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 6 / No. 1 / Published : 2013-02

Order : 6, and page :27 - 32

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Original Article :

Effectivity of gynura procumbens extract to inhibit vascular endothelial growth factor (vegf) expression on new blood vessels of chorioallantois membran (cam) chicken embryonal

Author :

  1. Hamid, I.S*1
  2. Dewi, R.K*2
  3. Nazar, D.S*3
  4. Ratnani, Hermin*4
  1. Fakultas Kedokteran Hewan Universitas Airlangga
  2. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

Angiogenesis is the new blood vessels formation normality and important on growth anddevelopment of individu. Angiogenesis also have contribution to carcinogenesis or uncontrolled andmalignant cancer cell development, become pathologic condition like inflammatory and infection. The purpose of this research for knew the effectivities of Gynura procumbens extract on various dose forinhibition VEGF expression. This research was done to effort cancer progress inhibition. However, angiogenesis is part of carcinogenesis causes. The Chorio Allantoic Membrane (CAM) methods wasused for this aim. Eggs at the age of nine days were divided into 6 groups. Group I were negativecontrol of vehicle, group II were zero treatment: 60 ng bFGF which aplicated into paper dish. Thenext four groups were extract of Gynura procumbens that divided in four dose: 60, 75, 90 and 110 µg+ bFGF 60 ng which applicated into  paper dish. At the twelve days old, VEGF expression analysiswas done which imunohystochemical method with ant i VEGF’s ant ibody.  The result of this research showed that there was significant different (p<0.05) on give of Gynura procumbens extract to VEGF expression. The most significant VEGF inhibition by Gynura procumbens extract with dose 110 µg.The conclusion on this study was Gynura procumbens extract effective to inhibit the VEGF expression on CAM embrio chick.

Keyword :

Angiogenesis, VEGF, Gynura procumbens, CAM,

References :

Bergers, G., and D, Hanahan ,(2008) Modes of resistance to anti-angiogenic therapy. . : Nat Rev Cancer 8: 592–603

Giovana, S. Di Marco., R, Stefan., H, Uta., A, Susanne., Maximilian., König., L, Etienne., O, Hans.,(2009) The Soluble VEGF Receptor sFlt1 Contributes to Endothelial Dysfunction in CKD. United States : Journal of the American society of Nephrology. vol. 20 no. 10 2235-2245

Archive Article

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Volume : 6 / No. : 1 / Pub. : 2013-02
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  5. Comparasion Of Chicken Humoral Immune Response Vaccinated With Active Ibd Lv-13ua And Lv-14ua Under Value Optical Density Indirect Elisa
  6. Effectivity Of Gynura Procumbens Extract To Inhibit Vascular Endothelial Growth Factor (vegf) Expression On New Blood Vessels Of Chorioallantois Membran (cam) Chicken Embryonal
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