UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 6 / No. 1 / Published : 2013-02

Order : 6, and page :27 - 32

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Original Article :

Effectivity of gynura procumbens extract to inhibit vascular endothelial growth factor (vegf) expression on new blood vessels of chorioallantois membran (cam) chicken embryonal

Author :

  1. Hamid, I.S*1
  2. Dewi, R.K*2
  3. Nazar, D.S*3
  4. Ratnani, Hermin*4
  1. Fakultas Kedokteran Hewan Universitas Airlangga
  2. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

Angiogenesis is the new blood vessels formation normality and important on growth anddevelopment of individu. Angiogenesis also have contribution to carcinogenesis or uncontrolled andmalignant cancer cell development, become pathologic condition like inflammatory and infection. The purpose of this research for knew the effectivities of Gynura procumbens extract on various dose forinhibition VEGF expression. This research was done to effort cancer progress inhibition. However, angiogenesis is part of carcinogenesis causes. The Chorio Allantoic Membrane (CAM) methods wasused for this aim. Eggs at the age of nine days were divided into 6 groups. Group I were negativecontrol of vehicle, group II were zero treatment: 60 ng bFGF which aplicated into paper dish. Thenext four groups were extract of Gynura procumbens that divided in four dose: 60, 75, 90 and 110 µg+ bFGF 60 ng which applicated into  paper dish. At the twelve days old, VEGF expression analysiswas done which imunohystochemical method with ant i VEGF’s ant ibody.  The result of this research showed that there was significant different (p<0.05) on give of Gynura procumbens extract to VEGF expression. The most significant VEGF inhibition by Gynura procumbens extract with dose 110 µg.The conclusion on this study was Gynura procumbens extract effective to inhibit the VEGF expression on CAM embrio chick.

Keyword :

Angiogenesis, VEGF, Gynura procumbens, CAM,


References :

Bergers, G., and D, Hanahan ,(2008) Modes of resistance to anti-angiogenic therapy. . : Nat Rev Cancer 8: 592–603

Giovana, S. Di Marco., R, Stefan., H, Uta., A, Susanne., Maximilian., König., L, Etienne., O, Hans.,(2009) The Soluble VEGF Receptor sFlt1 Contributes to Endothelial Dysfunction in CKD. United States : Journal of the American society of Nephrology. vol. 20 no. 10 2235-2245





Archive Article

Cover Media Content

Volume : 6 / No. : 1 / Pub. : 2013-02
  1. The Level Of Capric Acid Milk Cow On Consuming Complete Feed
  2. Injection Effect Of Mice (mus Musculus) Testes And Spleen Homogenat Derived Hy-antigen On Pup’s Sex Ratio
  3. The Colour Differences Between Escherichia Coli And Pseudomonas Aeruginosa Colonies In Artificial Medium That Was Made From Beef Extract, Mung Beans Juice, Citrate And Bromthymol Blue
  4. Effects Of Beef Packaging And Storage Temperature On The Early Beef Spoilage
  5. Comparasion Of Chicken Humoral Immune Response Vaccinated With Active Ibd Lv-13ua And Lv-14ua Under Value Optical Density Indirect Elisa
  6. Effectivity Of Gynura Procumbens Extract To Inhibit Vascular Endothelial Growth Factor (vegf) Expression On New Blood Vessels Of Chorioallantois Membran (cam) Chicken Embryonal
  7. Motility And Viability Thick Tail Ram’s Spermatozoa On Various Silver Ion (ag ) Concentration In Egg Yolk Citrate Coconut Water Assortment Extender
  8. The Isolation Of Escherichia Coli From The Meat Some Traditional Markets In The South Surabaya
  9. Conception Rate, Services Per Conception, Dan Calving Rate Setelah Ib Pada Sapi Potong Di Kabupaten Tulungagung Periode Januari – Desember 2010
  10. Motility And Life Percentage Of Friesian Holstein Bull’s Post Thawing Sperms In Egg Yolk Skim, Egg Yolk Tris And Andromed® Extenders
  11. Non Beta Lactam Antibiotics Resistance In Coagulase Positive Staphylococcus Isolated From Canine Pyoderma
  12. Study The Couples Of Bali Starlings (leucopsar Rothschildi) On Breeding Cages At Surabaya Zoo
  13. The Quality Of Etawa Goat-breed’s Frozen Semen In Various Types Of Diluent
  14. Identification Pandemic H1n1-2009 Virus On Pigs In Slaughterhouse Pegirian Surabaya By Using Hi Test
  15. Potential Of Concentrate Feed And Lactation Periods On Milk Protein And Feed Conversion On Dairy Cattle Friesian Holstein Crossbred

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