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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 4 / No. 1 / Published : 2011-02

TOC : 14, and page :77 - 80

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Original Article :

Excessive dose of vitamine a on skeletal development in the mice embryos

Author :

  1. Puspitadewi, T.R*1
  2. Poernomo, Bambang *2
  3. Darmanto, Win *3
  4. Prijatni, Ida *4
  1. .
  2. Fakultas Kedokteran Hewan Universitas Airlangga
  3. .
  4. .

Abstract :

Vitamin A is an essential nutrient for reproduction and development. Retinoic acid is one among lipid soluble form of vitamin A. The function of retinoic acid is regulator and transcription of gene. It takes time to excrete from the body, so that an excessive dosage will cause teratogenic effects especially in the skeletal development. In first trimester of pregnant mothers, in particularly, it may result abnormalities in mild and severe congenital and evenfetal death. However, chitosan (ß-1,4-2 amine-dioxy-D-glucosamine) could be reduce its effect through repairing chondrocyte tissue and bone damaged by stimulate the performing of extra cellular matrix protein of osteoblast and chondrocyte. The purpose of the research was to observed oral route effect of retinoic acid and reducing its effect through chitosan on the pregnant mice. This study was divided into two consecutive researches consist of 16 pregnant mice were induced by oral administered retinoic acid in a dose 60 mg/Kg body weight and 28 pregnant mice induced chitosan of several dose i.e.15, 30, and 45 mg/Kg body weight, respectively, oral administered following retinoic acid, both for congenital skeleta lobservation. Result conduct of the research was excessive retinoic acid which it induced on pregnancy mice will decreased number of delivery life fetus, on the contrary death and resorption fetus was increased. Meanwhile, the delay ossification of mice fetus witch it chitosan treatment has no significantly different for congenital fetal malformation

Keyword :

Retinoic acid, Chitosan, Pregnant mice, Congenital fetal malformation, .,

References :

  1. Puspitadewi, T.R., Darmanto W., and Poernomo B, (2008). Efek asam retinoat yang diberikan pada induk mencit (Mus musculus) umur kebuntingan 10 hari terhadap hasil reproduksi dan kelainan bawaan eksternal janin. Surabaya : Tesis (tidak diterbitkan). Program Pascasarjana
  2. Prijatni, I., Darmanto W., and Poernomo B., (2008). Pengaruh khitosan terhadap kelainan rangka janin mencit (Mus musculus) akibat asam retinoat. Surabaya : Tesis (tidak diterbitkan). Program Pascasarjana


Archive Article

Cover Media Content

Volume : 4 / No. : 1 / Pub. : 2011-02
  1. Production and specificity testing of monoclonal antibodies to bovine zonna pellucida 3 deglycosylated (mab-bzp3dg) for woman immunocontraceptive vaccine
  2. Potency of crude spirulina on protein efficiency ratio in laying hen
  3. H-y antisera preparation and x chromosomal receptor tracer as sex determination prototype
  4. Erythrocyte's form changes in dog's blood smear before and after the storage using citrate phosphate dextrose
  5. Avian influenza h5n1 vaccine candidate for chicken from east java isolate virus
  6. Pengaruh pemberian antagonis reseptor n-metil-d-aspartat (nmda) mk-801 terhadap penurunan sensasi nyeri inflamasi pada mencit putih (mus musculus) strain balb/c
  7. Exploration cellulolytic of bacterium of rumen liquid beef cattle as inoculum of waste agriculture
  8. Respon hmg toward ovarium development in goat
  9. Identification of pregnancy associated glycoprotein (pag) from milk of pregnant dairy cattle
  10. The role of soil as a helminths transmitter around the habitas of babirusa
  11. Potency of brown seaweed (sargassum duplicatum bory) ethanol and ethyl acetic fraction to malondialdehyde concentration decreasing and histological retriveal of ibd (inflammatory bowel disease) rat small intestinal jejunum
  12. Blood glucose and total blood protein profile in sheep provided with lactic acid bacteria and yeast on king grass and rice straw
  13. Effect of pegagan (centella asiatica) extract in ovariectomized wistar-strain rattus norvegicus on epithelial proliferation of vaginal wall
  14. Excessive dose of vitamine a on skeletal development in the mice embryos