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Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 1 / Published : 2014-02

TOC : 8, and page :49 - 56

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Original Article :

Histopathological view pyramid cell on cerebrum of white rat (rattus norvegicus) were exposed with methylmercury which administrated with cdp-choline as neuroprotective agent

Author :

  1. Agung Budianto Achmad*1
  2. Paulus Sugianto*2
  3. Widjiati*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Departemen Syaraf RSUD Dr Soetomo
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The experiment was conducted to know the histopathological view of pyramid cell on cerebrum of white rat (Rattus norvegicus)due to methylmercury exposure which administrated with CDP-Choline as neuroprotective agent. Twenty five rat’s divided into five group with 30 day treatment. The control grup (P0) was given 0,5 ml aquades, P1(methylmercury 0,02 mg/kg), P2(methylmercury 0,04 mg/kg), P3(methylmercury 0,02 mg/kg + CDP-Choline 100 mg/kg) and P4(methylmercury 0,04 mg/kg + CDP-Choline 100 mg/kg). ANOVA showed histopathological pyramid cell necrosis significantly different between group. Subsequently continued with Duncan multiple range test. Duncan test showed histopathological view of P0, P1 and P2, significanly different between group with P2 have higher necrosis rate than P0 and P1. Group P1 and P3 showed significanly different, with P3 have lower necrosis rate than P1, as well as with P2 and P4, group P4 have lower necrosis rate than P2. The conclusion of this research is methylmercury with dose 0,04 mg/kg (P2) has higher necrosis rate than the other group and CDP-Choline dose 100 mg/kg can protected pyramid cell from cell damage (necrosis), consequent from methylmerkuri exposure.

Keyword :

Methylmercury, CDP-Choline, Pyramid Cell, Necrosis,

References :

  1. Adibhatla R.M, J.F. Hatcher and R.J. Dempsey, (2002). Citilcoline:Neuro-protective Mechanism in Cerebral Ischemia. . : J. Neurochem. 80:12-23
  2. Arenth P.M, K.C. Russel, J.H. Ricker, R.D. Zafonte, (2011). CDP-Choline as Biological Supplement During Neurorecovery: A Focused Review. . : Am. Acad. Phy. Med. and Rehab. 3: S123-S131
  3. Aschner J.L and M. Aschner, (2007). Methylmercury Neurotoxicity: Exploring Potential Novel Target. . : J. Toxicol, 1:1-9


Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2014-02
  1. Grant of ethanol extract of seeds papaya (carica papaya) in female rats (rattus novergicus) antifertilitas material, as an alternative to number and quality of egg cells
  2. Effect of infusum salam leaves (eugenia polyantha) on blood glucose level on the rat (rattus norwegicus) in alloxan induced
  3. Potential of phytase ezymes from rumen bacteria on sem analysis structural changes of rice bran as broiler feed
  4. The comparison of morphology between bovine oocyte vitrification before and after in vitro maturation
  5. The effect of exposing pregnant rat (rattus novergicus) to particulate matter on congenital disorder and resorption of embryos
  6. Ha gene phyloanalysis of influenza h1n1 2009 virus in surabaya
  7. Effect of seminal plasm of cow on goat’s spermatozoa plasma membran in milk diluter on semen freezhing
  8. Histopathological view pyramid cell on cerebrum of white rat (rattus norvegicus) were exposed with methylmercury which administrated with cdp-choline as neuroprotective agent
  9. Giving epigallocathechin gallate (egcg) toward the expression of estrogen receptor at female white mouse (rattus norvegicus)
  10. Human resource management goad farm of the cross breed etawa goat independent farm, farmer groups and businesses in the town of turi sleman regency
  11. The pattern of antimicrobial susceptibility of salmonella sp isolated from beef
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  13. Potential of mycotoxin binders on weight and length of fetus pregnant mice (mus musculus) with zearalenone exposure
  14. Prevalence of worm disease in cattle gastrointestinal peranakan ongole (po) and simental cattle in the subdistrict laren, district lamongan
  15. The giving of anti- toxoplasma gondii membran immunoglobulin y before infection reduce apoptotic index liver mice