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Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

TOC : 4, and page :151 - 158

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Original Article :

Immune response of mice (mus musculus) by vaccinated brucella abortus strain rb 51 and infected with brucella suis toward spleen histopathology

Author :

  1. Maria Gladis Bupu Meze*1
  2. Emy Koestanti Sabdoningrum*2
  3. Sri Chusniati*3
  4. Lilik Maslachah*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this study was to knowthe number and diameter of white pulp of thespleen of mice (Mus musculus) by vaccinated Brucella abortus Strain RB51 and infectedBrucella suis. Eighteen mice were divided into three treatment groups which each groupconsists of six mice, P0- as negative control was given NaCl by intramuscular injection,meanwhile P0+ as positive control was infected with Brucella suis 1x108CFU/ml andP1 was vaccinated by Brucella abortus strain RB51 0,1 ml and infected by Brucellasuis1x108CFU/ml, and then sacrified at tenth week. The data of the number and diameterof white pulp of the spleen was examine with Nikkon H600L microskop. Then, the dataanalyzed using ANOVAtest and continued by HSDtest. The result of this study showedthere was significant (p˂0,05) different between negative control and treatment groupsbut not significant different with positive control.

Keyword :

Brucella abortus strain RB51, Brucella suis, mice, the number of white pulp, diameter white pulp,

References :

  1. Junqueira, L.C., (2010). Histologi Dasar. Edisi ke-12.. 251-276 : EGC Jakarta
  2. Pawar, S.K., M.V. Chorpade and R.D Totad, (2012). Brucellosis, an Unusual Etiology in PUO. 2(5):51-55 : Int. Journal of Health Science and Reserch
  3. Priadi, A., (2005). Infeksi Brucella suis Sebagai Penyakit Zoonosis. Lokakarya Nasional Penyakit Zoonosis.. 189-196 : Balai Penelitian Veteriner. Bogor


Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level of heat shock protein 70 and cortisol in bull’s serum before and after collecting semen
  2. Effectiveness of red fruit (pandanus conoideus linn) oil administration on infertile mice (mus musculus) serum luteinizing hormone and corpus luteum number
  3. The influence of beta carotene to live fetus percentage in mice (mus musculus) that exposured by cigarette smoke
  4. Immune response of mice (mus musculus) by vaccinated brucella abortus strain rb 51 and infected with brucella suis toward spleen histopathology
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