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Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

TOC : 15, and page :239 - 244

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Original Article :

Imunomodulator potention of alkaloid sambiloto (andrographis paniculata l) to ifnγ and cd4+ response after infected by salmonella typhimurium on the rat

Author :

  1. Imam Mustofa*1
  2. Wurlina*2
  3. Dewa Ketut Meles*3
  4. Sunarni Zakaria*4
  5. Niluh Suwasanti*5
  1. Dosen Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran
  5. Mahasiswa Fakultas Kedokteran

Abstract :

The aim of this research was to prove scientifically immunomudulator activities ofalkaloid sambiloto to adaptive immunity response in helping maintain the immune systemin common cold condition was caused by lack of immune system because of transmissionof infectious disease through examination of Interferon gamma (IFNγ) and sel helper(CD4+) that specific immune response. The research methods was activity of alkaloidsambiloto to innate immune response, that proved on 125 rats (Rattus norwegicus) thatdivided into 5 groups, which were control group (K), and 4 treatment groups. Controlgroup (P0) and treatments were infected by Salmonella typhimurium intraperitoneally105 CFU (P1,P2 and P3) then were given by alkaloid in various doses ( 0 mg/kg bw.,3,78 mg/kg bw., 7,56 mg/kg bw, and 11,34 mg/kg bw) for 10 days. The parameters thatobserved were IFNγ and CD4+. The research data that obtained were analyzed by one wayanava, if there was a different, then advanced analyze was done by smallest significantdifferential test. Research result was alkaloid sambiloto can decrease IFNγ and CD4+start from day 2 and back to normal after infected by Salmonella typhimurium.

Keyword :

Alkaloid Sambiloto, Salmonella typimurium, IFNγ, CD4+, .,

References :

  1. Mitruka, B., (1981). Clinical Biochemical and Hematological Reference Value in Normal Experimental Animal and Normal Humans. Second Edition.. 57-130 : USA
  2. Mustofa, I, Wurlina dan D.K Meles, (2015). Potensi Alkaloid Sambiloto (Andrographis paniculata L) terhadap Total Leukosit dan Hitung Jenis Leukosit pada Tikus setelsh diinfeksi Salmonella Typhimurium. 8(3): 301 -312 : Veterinaria Medika
  3. Wurlina, Imam Mustofa, Dewa Ketut Meles, Niluh Suwasanti, (2016). Potensi Alkaloid Sambiloto (Andrographis paniculata L) terhadap terhadap Total Leukosit dan Hitung Jenis Leukosit pada Tikus sebelum diinfeksi Salmonella Typhimurium. 9(2):173-184 : Veterinaria Medika


Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
  1. Level of heat shock protein 70 and cortisol in bull’s serum before and after collecting semen
  2. Effectiveness of red fruit (pandanus conoideus linn) oil administration on infertile mice (mus musculus) serum luteinizing hormone and corpus luteum number
  3. The influence of beta carotene to live fetus percentage in mice (mus musculus) that exposured by cigarette smoke
  4. Immune response of mice (mus musculus) by vaccinated brucella abortus strain rb 51 and infected with brucella suis toward spleen histopathology
  5. Activity of alkaloid of jarong leaves (achyranthes aspera linn ) on the death of cancer cells in the breasts of mice (mus musculus)
  6. Isolation and identification of edwardsiella tarda bacteria in clarias gariepinus place region in jombang
  7. Effect of rosella flower extract (hibiscus sabdariffa linn.) on kidney histopathologic of male mice (mus musculus) exposed lead acetate
  8. Isolation of keratinolytic bacteria from chicken feather waste
  9. The pathology of african catfish (clarias gariepinus) kidney infected by edwardsiella tarda
  10. Featuring liver pathology of clarias gariepinus that were infected by edwardsiella tarda
  11. The hepatoprotektor activity ofalkaloid sambiloto andrographis paniculata on the liver cell histopathological changes in male white rat rattus norvegicus induced paracetamol toxic dose
  12. Acute toxicity test alkaloid fraction of bittermelon (momordica charanthia l) to histopathological changes in the liver and kidneys of mice (mus tmusculus)
  13. The effects of vitamin c toward histopathology of stomach of mice exposed to endosulfan
  14. The effect of alkaloid achyranthes aspera linn on cytochrom c and apaf 1 expresion on mice breast cancer was induction by benzopyrine
  15. Imunomodulator potention of alkaloid sambiloto (andrographis paniculata l) to ifnγ and cd4+ response after infected by salmonella typhimurium on the rat
  16. Hepatoprotector activity sapogenin extract of sambiloto (andrographis paniculata) 0n alt and ast level on rat was induction paracetamol