Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 3 / No. 2 / Published : 2010-07

Order : 14, and page :147 - 150

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Original Article :

Influence of melatonin to histopathology pancreas in rat ( rattus norvegicus ) experimentally diabetes mellitus type i

Author :

  1. Boedi Setiawan*1
  2. Titis Agustianah*2
  3. Mustofa Helmi Effendi*3
  1. Fakultas Kedokteran Hewan Universitas Airlangga
  2. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

The aim of this study was obtained the influence of melatonin on histopathology pancreas in rat (Rattusnorvegicus) experimentally diabetes mellitus type I. Thirty healthy wistar male rat (Rattus norvegicus) with 100–150gram average body weight and two - three month old were used in this study. This rat were adapted for seven days anddivided into six group of treatment, that was P0, P1, P2, P3, P4, and P5. Treatment on group P0 as control negative, P1which injected by alloxan 150 mg/kg body weight as positive control of diabetes mellitus type I. Melatonin was givenintraperitoneally. Treatment on group P2 was injected by alloxan 150 mg/kg body weight and melatonin 5 mg/kg bodyweight, P3 was injected by alloxan 150 mg/kg body weight and melatonin 10 mg/kg body weight, and P4 was injectedby alloxan 150 mg/kg body weight and melatonin 15 mg/kg body weight, to observe the effective dose of melatonin astherapy of diabetes mellitus type I. Treatment on group P5 was injected by alloxan 150 mg/kg body weight and byinjecting forbetes which has known as drug of choice for diabetes mellitus type I, orally. This study used CompleteRandom Design and the result analyzed by using ANOVA (Analyzed of Variance) continued with Duncan's MultipleRange Test method and processed by using SPSS computer software program.The base result showed that melatonin can reduce Langerhans island cell damage in rat (Rattus norvegicus)eksperimentally diabetes mellitus type I. This showed the use of melatonin as the cure for diabetes mellitus type I is verygood and effective.

Keyword :

melatonin, alloxan, diabetes mellitus type I, ., .,

References :

McGavin, M. D., and J. F. Zachary,(2007) Pathologic Basis of Veterinary Disease United States : Mosby Inc.

Reiter, R.J., D. Tan, M.P. Terron, L.J. Flores., and Z. Czarnocki,(2007) Melatonin and its metabolites: new findings regarding their production and their radical scavenging actions Polonica : Acta Bio.

Ferry, R. P.,(2008) Pengaruh Pemberian Melatonin Terhadap Kadar Glukosa Darah Tikus Putih (Rattus norvegicus) Terpapar Alloksan Surabaya : Fakultas Kedokteran Hewan Universitas Airlangga

Archive Article

Cover Media Content

Volume : 3 / No. : 2 / Pub. : 2010-07
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  13. Isolation And Identification Of Coagulase-positive Staphylococcus From Injury On Dog Skin In Surabaya
  14. Influence Of Melatonin To Histopathology Pancreas In Rat ( Rattus Norvegicus ) Experimentally Diabetes Mellitus Type I