Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 2 / No. 2 / Published : 2009-07

Order : 9, and page :123 - 136

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Original Article :

Male infertility: sperm dna damage, reactive oxygen species (ros) and the key role of protamine molecule

Author :

  1. Muslim Akmal*1
  2. Aulanni’am*2
  3. Agung Pranowo W Mahendra*3
  1. Fakultas Kedokteran Hewan Universitas Syiah Kuala Darussalam Banda Aceh
  2. Fakultas MIPA Universitas Brawijaya, Malang
  3. Fakultas MIPA Universitas Brawijaya, Malang

Abstract :

Aproximately 50% of infertility issues are attributed to male factors. A numbers of different factors may result in similar reductions of sperm count or motility and affect sperm morphology. Not only is the etiology of male infertility difficult to understand, but it is equally challenging to treat male infertility because of its etiological heterogeneity. Protamine are the major DNA-binding proteins in the nucleus of sperm in most vertebrates and package the DNA in a volume less than 5% of a somatic cell nucleus. Human sperm contain similar amounts of protamine-1 (P1) and protamine protamine-2 (P2). Although aberrant protamine ratios have been observed in infertile men, functional evidence is provided by protamine knockout mice exhibiting male infertility. Protamines are essential for compaction of the sperm nucleus and to protect the DNA from damage. There is now clinical evidence to show that damage to human sperm DNA may adversely affect both poor embryo development and poor pregnancy outcomes. As sperm DNA integrity is known to be linked with DNA fragmentation and apoptosis. Sperm DNA damage and sperm dysfunction has been associated with high level of ROS.

Keyword :

sperm, reactive oxygen species (ROS), DNA, molekul protamine, .,

References :

Agarwal, A and T.M. Said,(2003) Role of sperm chromatin abnormalities and DNA damage in male infertility . : Human Reproduction Update

Aitken, R.J., E. Gordon and D. Harkiss,(1998) Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa . : Biol. Reprod

Aitken, R.J., and C. Krausz,(2001) Oxidative stress, DNA damage and the Y chromosome . : Reproduction

Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2009-07
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  2. Characterization Of Bacterial Surface Protein On Staphylococcus Aureus And Staphylococcus Epidermidis From Milk Cows With Mastitis
  3. The Sensitivity Of Coagulase Slide Test For Detection Of Staphylococcus Aureus On Bovine Mastitis Cases
  4. The Motility And Viability Of Entok (cairina Moschata) Spermatozoa In Diluter Of Skim Milk-fructosa
  5. The Effect Of Cryoprotectan Combination Dimethyl Sulfoxyde (dmso) And Glycerol At Frozen Semen Extender Of Cattle For Spermatozoa Quality Pasca Thawing
  6. Control Intra Vaginal Device Release (cidr) In Artificial Insemination Program Of Beef Catlle In Banyuwangi Region
  7. Water Injection On Waer Needling Acupuncture Analgesic Effect To Zusanli Acupoint Of White Rats (rattus Novegicus)
  8. Test Of Pharmacological Effect Of Eucheuma Spinosum Extract For Decreasing Blood Glucose Levels On Mice (rattus Novergicus) Induced Multi-low Dose Streptozotocin (mld Stz)
  9. Male Infertility: Sperm Dna Damage, Reactive Oxygen Species (ros) And The Key Role Of Protamine Molecule
  10. The Influence Of Lps ( Iipopolysaccharide) To Maltase Activity Isolated From Rattus Norvegicus Jejunum
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  12. Introduction Polyclonal Antibody Tyrosine Kinase As Alternative Immunocontraception Method Against Fertility Level Of Male Mice
  13. Bovine Oocytes In Vitro Maturation In Tcm 199 Supplemented By Bovine Hypophisis Extract
  14. The Effects Of Trehalose Level In Tris Based Diluter To Cross Breed Etawah Goat Spermatozoa Quality After Storage At Room Temperature
  15. The Fertility Acceptor Of Dairy Cow Artificial Insemination In Kpsp Setia Kawan Nongkojajar Tutur District Pasuruan Regency
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