UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 4 / No. 3 / Published : 2011-11

Order : 3, and page :171 - 174

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Original Article :

Pengaruh pemberian alkaloid daun jarong (achyranthes aspera linn) pada mencit yang terkena kanker mammae terhadap gambaran hitung jenis leukosit

Author :

  1. Yayuk Kholifah*1
  2. Wurlina*2
  3. Dewa Ketut Meles*3
  4. Sunarni Zakaria*4
  5. D.M.S. Putra*5
  6. N. Swasanti*6
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Fakultas Kedokteran UGM
  5. Fakultas Kedokteran UGM
  6. RS Condong Catur Jogyakarta

Abstract :

The aim of this study was to find out the effects of Achyranthes aspera Linn on differential leukocyte of mice with mammary cancer. This study use 20 mice at the age of 2 month that were divided become 5 groups. Each group were given B(a)P subcutaneous injection to induce mammary cancer for 2 months, twice a week, than every group were given different treatment. P0 was given suspension (CMC Na), P1, P2, and P3, were given suspensions by varying the dose of Achyranthes aspera Linn alkaloid (10 mg/kg bw, 30 mg/kg bw, and 100 mg/kg bw), while group K+ were treated with methotrexat. Treatment were given for 2 months by oral everyday. Mice were being euthanased after 2 moth treatment. Than mice blood were collected to made blood smear and stained with wright staining. Differential leukocyte were count under microscope. The result of this study indicate that alkaloid of Achyranthes aspera Linn had significant effect on neutrophil and lymphocyte amount, but it had no significant effect on the amount of monocyte, basophil, and eosinophil. Increase of neutrophil occured at the dose of 10 mg/kg bw, but compare with other group, it was concluded that the increase of neutrophil are caused by bacterial infection on this group instead of alkaloid. Statistical analysis showed that the alkaloid increase amount of lymphocyte at the dose of 30 mg/kg bw and 100 mg/kg bb. This study concluded that alkaloid of Achyranthes aspera Linn could be an imunomodulator to increase lymphocyte amount at mice with mammary cancer at the dose of 30 mg/kg bw and 100 mg/kg bw.

Keyword :

Achyranthes aspera Linn, Cancer, Leukocyte,


References :

Adyana, I.D.P,(2010) Ekspresi protein p53 dan cydline dependent kinase (CDK) pada kanker mammae mencit setelah pemberian fraksi alkaloid jarong (Achyranthes aspera linn) [M.Sc. Thesis] Surabaya : Fakultas Kedokteran Hewan Universitas Airlangga

Roya, G. And P.S.R. Zoo,(2000) Anticancer compound From Tissue Culture of Medical Plants of Herbal . : Medicinal Plants. Vol 7(2): 71-96

Meles dan K. Devy,(2008) Efek Fraksi Alkaloid Daun Jarong (Achyrantes aspera linn) pada Viabilitas Sel Mieloma Mencit Surabaya : Veterinary Medicine. Vol. 1 No.1





Archive Article

Cover Media Content

Volume : 4 / No. : 3 / Pub. : 2011-11
  1. Potential Carbofuran Induced Oxidative Stress, Decreased Choline Esterase And Increased Brain Cell Embryonal Death
  2. Crossbreds Entog And Duck Artificial Insemination Technology Of Diluted And Doses For Fertibily
  3. Pengaruh Pemberian Alkaloid Daun Jarong (achyranthes Aspera Linn) Pada Mencit Yang Terkena Kanker Mammae Terhadap Gambaran Hitung Jenis Leukosit
  4. Motilitas, Persentase Hidup Dan Keutuhan Membran Spermatozoa Domba Ekor Gemuk Post Thawing Dalam Tiga Macam Diluter
  5. The Quality Of Ram Sperm After Washing With Brackett And Oliphant’s (bo) Medium At Skim Milk And Egg Yolk Diluent
  6. Hematology Parameter Of Kacang Goats In Mojosarirejo Village Driyorejo Gresik
  7. The Utilization Of Ginger (zingiber Officinale ) As Natural Antibacterial On Pasteurized Milk Based On The Reduce Number Of Escherichia Coli
  8. Difference Optical Density405nm Value Antibody Of Layer Vaccinated With Infectious Bronchitis Active Monovalent And Infectious Bronchitis Activebivalent (ib-nd) By Using Indirect Elisa
  9. The Use Of Recycle Soybean Fermented Cake (tempe) With Cellulolytic Bacteria As Corn Substitution To Consumption Feed, Egg Production And Feed Convertion Ratio Of Layer Duck
  10. The Prevalence Of Helminthiasis Gastrointestinal Tract Of Sumatran Tiger (panthera Tigris Sumatrae) And Bengal Tiger (panthera Tigris Tigris) In Three Different Areas Of Conservation
  11. Supplement Of Acrosin To The Post Thawing Sperm Of Half-breed Of Etawa Goat (pe) Towards Capacitation And Acrosome Reaction Of Spermatozoa
  12. The Effectiveness Of Glutaraldehyde And Didecyl Dimethyl Ammonium Chloride Combination As A Disinfectant To Decrease Total Number Of Bacteria On Layer Chicken Cages
  13. Anti Hy Preparation As Raw Material For Frozen Semen And Frozen Female Embryos
  14. Aphrodisiac Bioscreening Models, Profile Of Justicia Gendarussa Burm.f., Pimpinella Pruatjan Molkenb And Pangium Edule Reinw. Extracts On Isolated Frog Gastric Smooth Muscle
  15. Application Of Human Menopose Gonadotrophin (hmg) Toward Follicle Growth In Cows Ovary Hypofunction

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