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Veterinaria Medika

ISSN 1979-1305

Vol. 4 / No. 1 / Published : 2011-02

TOC : 11, and page :57 - 64

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Original Article :

Potency of brown seaweed (sargassum duplicatum bory) ethanol and ethyl acetic fraction to malondialdehyde concentration decreasing and histological retriveal of ibd (inflammatory bowel disease) rat small intestinal jejunum

Author :

  1. Aulanni'am*1
  2. Anna Roosdiana*2
  3. Nur Lailatul Rahmah*3
  1. Jurusan Kimia Fakultas MIPA Universitas Brawijaya
  2. Jurusan Kimia Fakultas MIPA Universitas Brawijaya
  3. Jurusan Kimia Fakultas MIPA Universitas Brawijaya

Abstract :

Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease that attacks the digestive tract (specific in intestine and gastric). One of that causing IBD were indomethacin side effect as non-steroidal anti inflammatory drug. Exploration herbal material was developed countinously on medicinal treatment of IBD, include brown seaweed (Sargassum duplicatum Bory) extract from ethanol dan ethylacetic fraction. Indomethacin was used to induce small intestine inflammation with 15mg/kg body weight or ally once time and continued by theraphy of brown seaweed (Sargassum duplicatum Bory) ethanol dan ethylacetic fraction 100mg/kg body weight seven times for sevendays. Level of malondialdehyde (MDA) and histological picture of smal lintestine (jejunum) were used as parameter from effect Sargassum duplicatum Bory ethanol dan ethyl acetic fraction present to the small intestine inflammation. The MDA level was measured by TBA assay and histological picture was observed by hematoxylin-eosin staining. The result of this research showed that there were descent of MDA level 54.20%. The histological observation also showed  there were repaired on jejunum small intestine tissue. These result showed that Sargassum duplicatum Bory ethanol dan ethyl acetic fraction might be improved as alternatve theraphy on IBD medical treatment, especially small intestine inflammation. IBD

Keyword :

IBD, Indomethacin, Brown Sea Weed (Sargassum duplicatum Bory), MDA, .,


References :

  1. Meenakshi, S., D.Manicka Gnanambigai, S. Tamil M o z h i , M . A r u m u g a m a n d T . Balasu, (2009). Total Flavonoid and in vitro Antioxidant Activity of Two Seaweed of Rameshwaram Coast. United States : Global Journal of Pharmacology. 3 (2): 59-62.
  2. Ju, C. and J. P. Uetrecht. , (1998). Oxidation of a Metabolite of Indomethacin (Desmethyldeschlorobenzoylindomethacin) to Reactive Intermediates by Activated Neutrophils, Hypochlorus Acid, and The Myeloperoxidase System. United States : The American Society for Pharamcology and Experimental Therapeutic. 26 (7): 676-680
  3. Lim, S.N., P.C.K. Cheung, V.E.C. Ooi and P.O. Ang, (2002). Evaluation of Antioxidative of E x t r a c t s f r o m a B r o w n S e a w e e d , Sargassum siliquastrum. United States : J. Agric. Food Chem. 50: 3862-3866


   


Archive Article

Cover Media Content

Volume : 4 / No. : 1 / Pub. : 2011-02
  1. Production and specificity testing of monoclonal antibodies to bovine zonna pellucida 3 deglycosylated (mab-bzp3dg) for woman immunocontraceptive vaccine
  2. Potency of crude spirulina on protein efficiency ratio in laying hen
  3. H-y antisera preparation and x chromosomal receptor tracer as sex determination prototype
  4. Erythrocyte's form changes in dog's blood smear before and after the storage using citrate phosphate dextrose
  5. Avian influenza h5n1 vaccine candidate for chicken from east java isolate virus
  6. Pengaruh pemberian antagonis reseptor n-metil-d-aspartat (nmda) mk-801 terhadap penurunan sensasi nyeri inflamasi pada mencit putih (mus musculus) strain balb/c
  7. Exploration cellulolytic of bacterium of rumen liquid beef cattle as inoculum of waste agriculture
  8. Respon hmg toward ovarium development in goat
  9. Identification of pregnancy associated glycoprotein (pag) from milk of pregnant dairy cattle
  10. The role of soil as a helminths transmitter around the habitas of babirusa
  11. Potency of brown seaweed (sargassum duplicatum bory) ethanol and ethyl acetic fraction to malondialdehyde concentration decreasing and histological retriveal of ibd (inflammatory bowel disease) rat small intestinal jejunum
  12. Blood glucose and total blood protein profile in sheep provided with lactic acid bacteria and yeast on king grass and rice straw
  13. Effect of pegagan (centella asiatica) extract in ovariectomized wistar-strain rattus norvegicus on epithelial proliferation of vaginal wall
  14. Excessive dose of vitamine a on skeletal development in the mice embryos