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Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 3 / Published : 2014-11

TOC : 15, and page :298 - 803

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Original Article :

Potensi alkaloid achyranthes aspera linn terhadap ekspresi protein bax sel kanker payudara pada mencit (mus musculus) yang diinduksi benzopyrene

Author :

  1. Sunarni Zakaria*1
  1. Fakultas Kedokteran Universitas Airlangga

Abstract :

Cancer was a complete disease in the world, include in Indonesia. In 2010, WHO showed that cancer was a 2nd cause of death after cardiovascular disease, and a 6th cause a death in Indonesia. A third a cancer suffered was able to be cured before metastase case. When metastase phase occurred, mortality was high and needed an sppropriste chemotherapy treatment. Ideal chemotherapy medicine or anticancer was able to kill whole cancer cell without endanger a normal cell. Aims of research was to prove alkaloid potential within Achyranthes aspera Linn leaf to Bax protein expression in mice cancer mammae induced benzopyrene. Thirty female of mice aged 3-4 months, 20-30 gram of body weight. Female divided into 5 treatment groups which consisted of six mice. Mice wasinjected by benzopyrene intra mammae 10 mg/kg body weight, twice a week during 8 weeks in order to infect a cancer of mammae. A cancer signed by swollen in mice’s mammae and proven by proliferation mammae cell in histopathological representation. Then, mice got therapy used alkaloid Achyranthes aspera Linn fraction peroral through negative control treatment were health mice, 4 groups of mice suffer of mammae cancer P0, P1, P2, and P3 which each group treated Metotreksatdosis 30 mg/kg body weight, 60 mg/kg body weight, and 100 mg/kg body weight. Result of Bax protein expression research after stastical test showed significant differences in 5 groups treatment, as large dose of Achyranthes aspera Linn as Bax protein expression. Conclusion Achyranthes aspera Linn which was given peroral caused improvement of Bax protein in mice mammae cancer induced benzopyrene thus could improve apoptosis and used to be anticancer.

Keyword :

Benzopyrene, Breast cancer cell, Mice, Aschyranthes aspera, Bax protein,

References :

  1. Chakraborty, A., A. Branther, T. Mukainaka, T. Konoshima, H. Tokuda and H. Nishino, (2002). Cancer hemopreventive Activity of Achyranthes aspera L Leaves on Eipsten Barr Virus Activation and Two stage Mouse Skin carcinogenesis. . : Cancer Let.Mar. 177(1) : 1-5
  2. Kim M.J., D.H. Kim, K.W. Lee, D.Y. Yoon and Y.J. Surh, (2007). Alkaloid Induces Apoptosis in Ras Transformed Human Breast Epithelial Cells Through generation of Reactive Oxygen Species. New York : New York Academy of Sciences. 483 – 495
  3. Weinberg R.A., (2007). Tumor suppressor genes. New York : In The Biology of Cancer, New York, Garland Sc. 209-254


Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2014-11
  1. The accuracy of production equine chorionic gonadotropin (ecg) frozen dry from local horse for increasing the time onset of oestrus in madura cattle
  2. Effect of infusum kopi leaves (coffea robusta lindl.) on blood glucose level on the mice in alloxan induced
  3. Comparison of sperm quality after separation x and y chromosome between column albumin method and electric separating sperm (ess) method on ekor gemuk sheep
  4. Potential of vitamin e on spermatogenic cell number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  5. The comparison of maturation between bovine oocyte vitrification before and after in vitro maturation
  6. Potency of pediococcus pentosaceus protease on meat tenderness and histological
  7. Effect of vitamin e on decreased of the leydig cell necrosis number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  8. The immunomodulator potency of combination of andrographis paniculata and echinacea purpurea on total and differential leucocytes count in mice with heat stress
  9. The effect of various egg duck concentration in skim milk as semen diluters of fat-tailed sheep for motility, viability and intact plasma membrane spermatozoa before freezing
  10. Antibacterial effect of mango’s leaves (mangifera indica) extract against staphylococcus aureus and escherichia coli
  11. Effectiveness of honey and the juice of noni (morinda citrifolia linn) as well as mixtures of the number of bacteria on chicken carcasses
  12. The potential of soursop (annona muricata linn.) leaves extract as immunostimulantin rabbit pbmc
  13. Crude protein and crude fiber in rice bran fermented by acidothermus cellulolyticus or aspergillus terreus wpl 109 or wpl 209
  14. Level of contamination of salmonella sp in white prawns (litopenaeus vannamei) sold at some wet and modern market in surabaya
  15. Potensi alkaloid achyranthes aspera linn terhadap ekspresi protein bax sel kanker payudara pada mencit (mus musculus) yang diinduksi benzopyrene