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Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 1 / Published : 2014-02

TOC : 13, and page :81 - 86

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Original Article :

Potential of mycotoxin binders on weight and length of fetus pregnant mice (mus musculus) with zearalenone exposure

Author :

  1. Nowo Siswo Yuworo,*1
  2. Abdul Samik*2
  3. Dikky Eka Mandala P*3
  4. Kartika Eka Paksi*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Mahasiswa Fakultas Kedokteran Hewan
  4. Mahasiswa Fakultas Kedokteran Hewan

Abstract :

Zearalenone (ZEN), an estrogenic mycotoxin, is produced mainly by Fusarium fungi. Previous studies indicated that acute ZEN exposure induced oxidative stress and damage in multiple organs. In order to study the potential mycotoxin binders to eleminate the effect of zearalenon and to decrease apoptotic factors in fetal. The research has been done on Desember 2013 till January 2014. We used 20 pregnant mices randomly divided into 5 groups and each other have 4 examination. All groups were given treatment per oral with sonde till 10 days. K+ as positive control weren’t treated zearalenone and mycotoxin binders, K- as negative control were treated with zearalenone 0,1 mg/mice/day, P1 were treated with zearalenone 0,1 mg/mice/day and mycotoxin binders 0,5 mg/mice/day, P2 were treated with zearalenone 0,1 mg/mice/day and mycotoxin binders 1 mg/mice/day, P3 were treated with zearalenone 0,1 mg/mice/day and mycotoxin binders 2 mg/mice/day. The data was analyzed by ANOVA and to compare the mean differences among treatments tested by Duncan’s multiple range test. The result showed that the amount of weight not significant (p>0,05) between K- with K+, P1, P2, P3. The lenght not significant between P2, P3 with K+, K-, P1. The conclusion in this study, mycotoxin binders was not significant to reduce weight and lenght fetus of pregnant mice with exposure zearalenone

Keyword :

Zearalenone, Mycotoxin binders, Weight and length of fetus, Pregnant mice (Mus musculus),

References :

  1. Abid-Essefi, S., Z. Ouanes., W. Hassen., I. Baudrimont., E. Creppy., and H. Bacha, (2004). Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone. . : J.Toxicol In Vitro. 18: 467– 474
  2. Döll, S., S. Dänicke., H. Valenta and G. Flachowsky, (2004). In vitro studies on the evaluation of mycotoxin detoxifying agents for their efficacy on deoxynivalenol and zearalenone. . : J. Arch. Anim. Nutr. 58: 311-324
  3. Zinedine, A., JM. Soriano., JC. Molto., and J. Manes, (2007). Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. . : Food and Chemical Toxicology. Vol 45: 1-18.


Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2014-02
  1. Grant of ethanol extract of seeds papaya (carica papaya) in female rats (rattus novergicus) antifertilitas material, as an alternative to number and quality of egg cells
  2. Effect of infusum salam leaves (eugenia polyantha) on blood glucose level on the rat (rattus norwegicus) in alloxan induced
  3. Potential of phytase ezymes from rumen bacteria on sem analysis structural changes of rice bran as broiler feed
  4. The comparison of morphology between bovine oocyte vitrification before and after in vitro maturation
  5. The effect of exposing pregnant rat (rattus novergicus) to particulate matter on congenital disorder and resorption of embryos
  6. Ha gene phyloanalysis of influenza h1n1 2009 virus in surabaya
  7. Effect of seminal plasm of cow on goat’s spermatozoa plasma membran in milk diluter on semen freezhing
  8. Histopathological view pyramid cell on cerebrum of white rat (rattus norvegicus) were exposed with methylmercury which administrated with cdp-choline as neuroprotective agent
  9. Giving epigallocathechin gallate (egcg) toward the expression of estrogen receptor at female white mouse (rattus norvegicus)
  10. Human resource management goad farm of the cross breed etawa goat independent farm, farmer groups and businesses in the town of turi sleman regency
  11. The pattern of antimicrobial susceptibility of salmonella sp isolated from beef
  12. Potential mycotoxin binders on histopathology of the mammary gland experiencing neoplasia in pregnant mice (mus musculus) with exposed zearalenone
  13. Potential of mycotoxin binders on weight and length of fetus pregnant mice (mus musculus) with zearalenone exposure
  14. Prevalence of worm disease in cattle gastrointestinal peranakan ongole (po) and simental cattle in the subdistrict laren, district lamongan
  15. The giving of anti- toxoplasma gondii membran immunoglobulin y before infection reduce apoptotic index liver mice