UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 6 / No. 2 / Published : 2013-07

Order : 11, and page :133 - 138

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Original Article :

The effect of borax to duodenal histopathological changes in rats (rattus norvegicus)

Author :

  1. Purnama, M.T.E*1
  2. Widjaja, N.M.R*2
  3. Plumeriastuti, Hany*3
  1. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  2. Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

The purpose of this study was to evaluate the histopathological changes in duodenum of wistar rats after giving borax using different subchronic toxicity doses. The research has been done on April, 2 2012-May, 29th 2012 at Department of Veterinary Pathology , Faculty of Veterinary Medicine, University of Airlangga. Twenty male rats (Rattus norvegicus strain Wistar) aged 45 days with BW 100 g were used.These animals were divided into four groups (P0, P1, P2, and P3). P0 were treated with sterile aquadest0,5 ml/rats/day, P1 were treated with borax 19 mg/rats/day, P2 were treated with borax 26 mg/rats/day,and P3 were treated with borax 37 mg/rats/day. This research has been conducted for 14 days to determine the toxic effects of borax on the duodenum. The data were compared using Kruskal-Wallis testand Mann-Whitney test. Statistical comparisons were performed using SPSS v20.0 for windows. The result showed that borax significantly caused cloudy swelling, congestion, necrosis and erosion of the villi on duodenal histopathology (p<0,05).

Keyword :

Disodium tetraborate decahydrate, Duodenal histopathology, Borax,


References :

Dieter, M.P.,(1994) Toxicity and carcinogenicity studies of boric acid in male and female B6C3F1 mice. . : Environ. Health Persp. 102(Suppl 7):93-97.

Sugiyatmi, S. ,(2006) nalisis Faktor-Faktor Risiko Pencemaran Bahan Toksik Boraks dan Pewarna pada Makanan Jajanan Tradisional yang Dijual Di Pasar-Pasar Kota Semarang Tahun 2006 Semarang : [Tesis]. Program Pasca Sarjana Universitas Diponegoro. Semarang. 3-21.





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