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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 2 / Published : 2014-07

Order : 10, and page :158 - 165

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Original Article :

The effect of cosmos caudatus leaf ethanol extract on paracetamol induced in histopathologic liver of (mus musculus) balb / c male

Author :

  1. Silvi Noor Khofiyah*1
  2. Ajik Azmijah*2
  3. Erni Rosilawati Sabar Iman*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This study aims to determine the effect on the prevention of liver damage by leaf extract kenikir (Cosmos caudatus) on histopathologic liver in mice (Mus musculus) induced paracetamol. This study used 25 mice BALB / C male age 2-3 months with an average weight of 20-25 grams, were randomly selected and inserted into 5 treatment groups K (-), K (+), P1, P2, P3. K (-) is the negative control group was given distilled water for 14 days, K (+) is the positive control group were given paracetamol on the last day of treatment (the 14th day), P1 is the treatment group were given extracts of leaves of kenikir dose of 200 mg/kg paracetamol for 14 days and on day 14, P2 is a given treatment group kenikir leaf extract dose of 400 mg/kg for 14 days and paracetamol on day 14, P3 is a given treatment group kenikir leaf extract dose of 800 mg/kg for 14 days and paracetamol on day 14. On the 15th day of experimental, animals dissected and taken to the liver organ preparations made preparations histpatologis liver of mice. This study used a completely randomized design (CRD), the data obtained were processed with the Kruskal-Wallis test. If there is a real difference will be followed by Mann Whitney test. Statistical analysis using SPSS. The results showed that at a dose of 800 mg/kg may provide hepatoprotective effect against changes in liver cell degeneration and necrosis induced best compared paracetamol dose of 200 mg/kg and a dose of 400 mg/kg.

Keyword :

Paracetamol, Kenikir leaf extract, Hepatoprotector,


References :

Adegroba, M.A., E.K. Okoh, T.A. Adelanwa and E.M. Obuotor,(2004) Antioxidant properties of the Nigerian Piliostigma Species . : J.Biol.Sci. 4(4): 501-503

Adji, D.,(2009) Perubahan Fungsi Hepar Dan Ekspresi C-Reactive Protein (CRP) Pasca Operasi Laparatomi Yogyakarta : J. Sain Vet.27 (2)

Crawford, J.M.,(2007) Liver and biliary tract. In: Kumar V, Abbas Ak, Fausto N. Robbins and Cotran pathologic basis of disease. 7th ed . : Philadelphia: Elsevier Saunders. 880-1,903





Archive Article

Cover Media Content

Volume : 7 / No. : 2 / Pub. : 2014-07
  1. The Influence Of Carbofuran Exposure Toward White Pulp Diameter Of Spleen Of Mice (mus Musculus)
  2. Antibacterial Activity Of The Supernatant Of Soil Isolate Bacillus Subtilis Against Aeromonas Hydrophila And Staphylococcus Aureus (in Vitro)
  3. The Potential Of Giving Synbiotic In Different Ages Of Female Broilers On Histological Of Ileum
  4. Evaluation Toluidine Blue Staining To Identify Connective Tissue Mast Cells (ctms) In Paraffin Block Thin Skin Of Dog
  5. Effect Using A Combination Of Mpa (medroxy Progesterone Acetate) And Prostaglandin (pgf2α) Injection On The Percentage Of Estrous And Pregnant On Sheeps
  6. Spesifisity Test With Dot Blotting Of Epidermal Growth Factor (egf) Isolated From Cumulus Oocyte Complex After In Vitro Maturation
  7. Analysis Of Immunogenicity On Inactivated Dengue Virus (denv-1, Denv-2, Denv-3, Denv-4) In Mices (mus Musculus) As A Candidate Dengue Coctail Vaccine
  8. Detection Antibody Of Brucella On Cattle Slaughtered In Krian Slaughter House Sidoarjo Regency By Rose Bengal Test (rbt)
  9. The Effect Of Didecyldimethylammonium Chloride Disinfectants On Liver Histophatolologycal Of Duck Hybrid (anas Platyrhynchos Domesticus)
  10. The Effect Of Cosmos Caudatus Leaf Ethanol Extract On Paracetamol Induced In Histopathologic Liver Of (mus Musculus) Balb / C Male
  11. Antibacterial Test Of Rumbia Root (metroxylon Sagu Rottb.) Decoction Against Bacteria Salmonella Pullorum
  12. Effect Of Sambiloto Leaf Extract (andrographis Paniculata Ness) To Histopathological Pancreatic Langerhans Islet Cells On Rats (rattus Norvegicus) With Cystic Ovary Model
  13. Effect Of Mangosteen (garcinia Mangostana L.) Pericarp Extract On Tlr5 And Cd14 Expression In Immunized Mice Against Newcastle Disease Vaccine
  14. Cloning Gene Fragments Non-structural 1 (ns1) Of Dengue Virus Subtype 1 (denv-1) As A Material Candidate Of Vaccine Chimera
  15. Effect Of Vitamin E (α–tocopherol) On The Number Of Leydig Cell In Mice Treated With 2,3,7,8–tetrachlorodibenzo-p-dioxin (tcdd)

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