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Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 2 / Published : 2016-07

TOC : 16, and page :203 - 208

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Original Article :

The effect of extract meniran (phyllanthus niruri linn.)to ileum histopathological changes in ratsinduced by alcohol

Author :

  1. Angga Pratomo Cahyadi*1
  2. Djoko Legowo*2
  3. Kusnoto*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Meniran is one of the traditional medicine plant. It has function as antioxidant, anti-inflammation, antipyretic, antitoxic, and antibacterial. Solution of extract meniran can minimalize damage of organ, for example ileum. The aim of this study was to investigate the positive effect of Phyllanthus niruri Linn extract on histopathological ileum of Rattus norvegicus strain Wistar induced by alcohol. Twenty Rats with an average at 200 grams were induced by alcohol in 25% concentration. Rats on three groups (P2 0.63mg/rats/day, P3 2.7mg/rats/day, and P4 6.26mg/rats/day) induced by Phyllanthus niruri Linn for 7 days then induced by Phyllanthus niruri Linn and alcohol 25% for 14 days, group P0 induced by CMC Na 1 % for 21 days, group P1 induced by alcohol 25% for 14 days. Where P0 was negative control group. Experimental design using a completely Federer design with five replications on each treatment. The data of histopathological changes of ileum was analyzed with Kruskall Wallis test and Z test. The research showed there were no significantly differences of ileum histopathological changes between P0 and P4. It was proved that P4 was most effective dose in reducing histopathological changes.

Keyword :

Phyllanthus niruri Linn, Ileum histopathology, Alcohol,

References :

  1. Barthel, et al., (2003). Salmonella enteric serovar typhimurium colitis model that allows analysis of both pathogen and host. 71: 2839–2858 : Journal of Infection and immunity
  2. Budiarta, S., dan Sudarmadi, GM., (2003). Jurnal Histologi Intestinum pada Hewan Besar. . : Fakultas Kedokteran Hewan Universitas Gadjah Mada Yogyakarta
  3. Dalimarta, S., (2000). Atlas Tumbuhan Obat Indonesia. . : Trubus, Agriwidya: Bogor


Archive Article

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Volume : 9 / No. : 2 / Pub. : 2016-07
  1. Therapy effect of (pandanus conoideus inn) on female mice (mus musculus) infertility model toward the folicle diameter size of pre antral and antral histopathological features
  2. The effects of insulin transferin selenium supplementation on mice (mus musculus) embryos vitrification media at morula stage towards the viability of blastomere cells using fluorescence techniques after warming
  3. Staphylococcus aureus contamination rate on beef slaughter results in pegirian surabaya slaughterhouse
  4. Response of antibodies formed as result of brucella suis infection in mice (mus musculus) with complement fixation test (cft)
  5. Therapeutic effect of spirulinaplatensis extract on histopathological appearance of ethanol induced liver injury in rat (rattus norvegicus)
  6. Detection gene coding capsule type a of pasteurella multocida from cases of fowl cholera by polymerase chain reaction
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  9. Utilization of coconut shell liquid smoke as preservation in chicken intestine on the value of total plate count
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  14. Influence of red betel leaf’s extract (piper crocatum) to the histopatology image on rat’s skin which infected by staphylococcus aureus
  15. Characteristic morphology and biochemical of cellulolytic isolate cytophaga sp
  16. Red cell count (erythrocyte), hematocrit, and hemoglobin of catfish (clarias gariepinus) after infected by aeromonas hydrophila
  17. The effect of extract meniran (phyllanthus niruri linn.)to ileum histopathological changes in ratsinduced by alcohol