Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 6 / No. 2 / Published : 2013-07

Order : 4, and page :97 - 102

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Original Article :

The effect of green bitter melon fruit flesh (momordica charantia l.) extract on mice (mus musculus) estrous cycle which superovulated with pmsg and hcg

Author :

  1. Agustina, G.A*1
  2. Mustofa, Imam*2
  3. Sunarso, Agus*3
  1. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  2. Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

This study aimed to determine the effect of bitter melon fruit flesh (Momordica charantia L.) extract onmice (Mus musculus) estrous cycle which superovulated with PMSG and hCG. Bitter melon fruit isknown to contain flavonoids and triterpenoids that are antigonadotropin. Thirty two head of mice were randomly divided into four groups, then superovulated by using 5 IU PMSG and 5 IU hCG intraperitoneally. The study used bitter melon fruit flesh exstract dosage 0 mg/g bw, 0.667 mg/g bw, 1.00mg/g bw, and 1.33 mg/g bw in 5% CMC respectively. Treatment carried 0.5 ml orally twice a day for tendays. Identification of estrous cycle conducted by examining vaginal smear administered four times aday, for ten days after treatment. The results of the study showed that the bitter melon fruit flesh extractwas not significantly (p>0.05) affect of proestrous and metestrous phase. All dose of bitter melon fruitflesh extract in this study was significantly extend (p<0,05) of estrous phase, meanwhile 1.00 mg/g bw and 1.33 mg/g bw dose of bitter melon fruit extract was significantly shorten (p>0,05) of diestrus phase.There were significantly extend (p<0,05) of mice treated with all dose of bitter melon fruit fleshcompared to nontreated mice. 

Keyword :

Mice, Bitter melon fruit, Estrous cycle,

References :

Rusmiati.,(2010) Pengaruh Ekstrak Metanol Kulit Kayu Durian (Durio zibethimus Murr) pada Struktur Mikroanatomi Ovarium dan Uterus Mencit (Mus musculus L.) Betina. Indonesia : Sains dan Terapan Kimia. 4(2):114.

Fitrianti, F.,(2001) ubungan Kadar Estradiol dan Progesteron dengan Panjang Siklus Estrus Tikus Putih (Rattus sp.) yang Disuperovulasi Bogor : [Skripsi]. Fakultas Kedokteran Hewan Institut Pertanian Bogor.

Archive Article

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Volume : 6 / No. : 2 / Pub. : 2013-07
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  4. The Effect Of Green Bitter Melon Fruit Flesh (momordica Charantia L.) Extract On Mice (mus Musculus) Estrous Cycle Which Superovulated With Pmsg And Hcg
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