Veterinaria Medika
ISSN 1979-1305
Vol. 8 / No. 2 / Published : 2015-07
Order : 12, and page :193 - 198
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Original Article :
The effect of mangosteen peel extract (garcinia mangostana l.) to the number of placental trophoblast cells in mice (mus musculus) exposure to cigarette smoke
Author :
- Cristianita M. Tany*1
- Widjiati*2
- Sri Pantja Madyawati*3
- Mahasiswa Fakultas Kedokteran Hewan
- Dosen Fakultas Kedokteran Hewan
- Dosen Fakultas Kedokteran Hewan
Abstract :
The purpose of this study was to find out the effect of mangosteen peel extract (Garcinia mangostana L.) to the number of placental trophoblast cells in mice (Mus musculus) exposure to cigarette smoke. Experimental animals were used 25 pregnant mice strain Balb / c, and then divided into five groups K-, K+, P1, P2, and P3. K- was only given distilled water during day 6 to day 17 of gestation, K + was given exposure to cigarette smoke during day 6 to day 17 of gestation, P1, P2, and P3 were exposured to cigarette smoke and given mangosteen peel extract at a dose of 50 mg / kg body weight, 100 mg / kg body weight, 150 mg / kg body weight during gestation day 6 to day 17. The sample used in this study was 25 plasenta. Data were analyzed using ANOVA and Tukey test. The results showed significant differences in the number of placental trophoblast cells of mice between treatment groups. According to research results, a dose of 100- 150 mg / kg BW has a large effect on the reduction in the number of placental trophoblast cell death and had the optimum dose to inhibit the placental trophoblast cell death.
Keyword :
Garcinia mangostana L., placental trophoblast cells, cigarette smoke,
References :
Chomnawang, M.T., S.Surassmo., V.S. Nukoolkarn and W.Gritsanapan,(2007) Effect of Garcinia mangostana on Inflammation Caused by Propionibacteriumacnes 78: 401–8 : Fitoterapia
Kaihena, M., Syamsu., Y. Yasir and M. Hatta,(2015) The effect of the petroleum ether extracts from mangosteen pericarp (Garcinia mangostana L.) on interferon-gammaand, interleukin-12 activities in albino wistar rats (Rattus norvegicus) Infected with Mycobacterium tuberculosis 3 (1): 8- 13 : American Journal of Microbiological Research
Sie, J.,(2013) Daya Antioksidan Ekstrak Etanol Kulit Buah Manggis (Garsinia mangostana L.) Hasil Pengadukan Dan Reflux 2 (1) : Jurnal Ilmiah. Universitas Surabaya
Widjiati, S.E. Pusporini dan A.M. Zainal,(2012) Perbandingan Angka Fertilitas dan Hambatan Perkembangan Embrio Mencit yang Dikultur dalam Medium M16 dan Human Tubal Fluid 13 (3) : 227-234 : Jurnal Veteriner
Archive Article
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Volume : 8 / No. : 2 / Pub. : 2015-07 |
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