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Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 2 / Published : 2017-07

TOC : 11, and page :209 - 218

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Original Article :

The hepatoprotektor activity ofalkaloid sambiloto andrographis paniculata on the liver cell histopathological changes in male white rat rattus norvegicus induced paracetamol toxic dose

Author :

  1. Mamdukhah Maharani*1
  2. Dewa Ketut Meles*2
  3. Lita Rakhma Yustinasari*3
  4. Wurlina*4
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan

Abstract :

The aims of this research was to determine the hepatoprotector activity of alkaloidsambiloto of Andrographis paniculata on the liver cell histopathological in male whiterat Rattus norvegicus after paracetamol induction. The activity of alkaloid sambilotoAndrographis paniculata was tested in 25 rats.Twenty five male white rat of Wistar strainwere randomly divided into five groups; K(-) as negative control was given carboxymethyl cellulosa, Po as positive control was given 250 mg/kg bw of paracetamol, P1 wasgiven alkaloid sambiloto of 3.78 mg/200g bw/day, P2 was given alkaloid sambiloto of7.56 mg/200g bw/day, and P3 was given alkaloid sambiloto of 11.34 mg/200g bw/day. Onthe 10 day of experimental, Po, P1, P2, and P3 was given 250 mg/kg bw of paracetamol.Paracetamol solutions on P1, P2 and P3 groups treated in a hour after each groups treatedwith alkaloid sambiloto (Andrographis paniculata) solutions. The treatment were givenby oral. The treatment were done every day for 10 day. On the 11 day of experimental,rat dislocated cervicalis and the liver organ was taken to make histopathologis sample.The sample were observed increased degeneration and necrosis of liver cells. The samplewere compared and showed no significant difference. In conclusion, alkaloid sambiloto(Androgrphis paniculata) couldn’t prevent damage to liver cells of male white rat (Rattusnorvegicus) after induced paracetamol.

Keyword :

paracetamol, alkaloid sambiloto, istopathologic,

References :

  1. Arsad, S. S., N. M. Esa., H. Hazilawati, (2014). Histopathologic Changes in Liver and Kidney Tissues from Male Sprague Dawley Rats Treated with Raphidophora Decursiva (Roxb.) Schott Extract. S4(001): 1-6 : J Cytol Histol.
  2. Bebenista, M., and J. Nowak, (2014). Paracetamol: Mechanism of Action, Applications and Safety Concern. 71(1):11-23 : Acta Poloniae Phamaceutica- Drug Research
  3. Elmore, S., (2007). Apoptosis: A Review of Programmed Cell Death. 35(4):495–516 : Toxicol Pathol.


Archive Article

Cover Media Content

Volume : 10 / No. : 2 / Pub. : 2017-07
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  11. The hepatoprotektor activity ofalkaloid sambiloto andrographis paniculata on the liver cell histopathological changes in male white rat rattus norvegicus induced paracetamol toxic dose
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