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Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 3 / Published : 2014-11

TOC : 8, and page :254 - 259

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Original Article :

The immunomodulator potency of combination of andrographis paniculata and echinacea purpurea on total and differential leucocytes count in mice with heat stress

Author :

  1. Dewa Ketut Meles*1
  2. Purnaning Dhian Isnaeni*2
  3. Wurlina*3
  4. Sri Mumpuni*4
  5. Niluh Suwasanti*5
  1. Dosen Fakultas Kedokteran Hewan
  2. Mahasiswa Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan
  4. Dosen Fakultas Kedokteran Hewan
  5. PPDS Patologi Klinik RS Sutomo

Abstract :

One of immune system components that had function to protect the body was white blood cell. Disturbance of immune system could cause the pathogen infect the body. One of the disturbances of immune system was stress, such as heat stress. Andrographis paniculata contained active compound andrographolide and Echinacea purpurea had polysaccharides compound that possesses immunomodulatory effect. This research used combination of Andrographis paniculata and Echinacea purpurea as immunomodulator on mice treated with heat stress in 39-400C. This research used 70 mice with different treatments: P0 (without immunomodulator), P1 (dosage of immunomodulator given was 0.00364 caps/mice/day), P2 (two times of P1 dosage), and P3 (two times of P2 dosage). The total and differential leucocyte count was done every week for four weeks. The result was analyzed by ANOVA and Tukey test, and resulted significant difference on total leucocyte count on first and third week. Significant differences were also seen on eosinophil count on first week, segmented neutrophil on third week, and limphocyte count on third week

Keyword :

Andrographis paniculata, Echinacea purpurea, Immunomodulator,

References :

  1. Dhabhar, F. S, (2006). Stress-induced Changes in Immune Cell Distribution and Trafficking: Implication for Immunoprotection versus Immunopathology In: C. J. Welsh, M. W. Meagher, and E. M. Sternberg (Ed.). Neural and Neuroendocrine Mechanism in Host Defense and Autoimmunity. New York : Springer Science+Business Media
  2. Vora, A. C, (2007). Role of Immunomodulators in the Management of MDR-TB. India : The Association of Physcians of India. Medicine Updates. 775-778
  3. Xu, Youhong, (2009). Adaptive Immune Response-modifying and Antimicrobial Properties of Andrographis paniculata and Andrographolide. Queensland : [Dissertation Doktor]. The University of Queensland


Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2014-11
  1. The accuracy of production equine chorionic gonadotropin (ecg) frozen dry from local horse for increasing the time onset of oestrus in madura cattle
  2. Effect of infusum kopi leaves (coffea robusta lindl.) on blood glucose level on the mice in alloxan induced
  3. Comparison of sperm quality after separation x and y chromosome between column albumin method and electric separating sperm (ess) method on ekor gemuk sheep
  4. Potential of vitamin e on spermatogenic cell number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  5. The comparison of maturation between bovine oocyte vitrification before and after in vitro maturation
  6. Potency of pediococcus pentosaceus protease on meat tenderness and histological
  7. Effect of vitamin e on decreased of the leydig cell necrosis number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  8. The immunomodulator potency of combination of andrographis paniculata and echinacea purpurea on total and differential leucocytes count in mice with heat stress
  9. The effect of various egg duck concentration in skim milk as semen diluters of fat-tailed sheep for motility, viability and intact plasma membrane spermatozoa before freezing
  10. Antibacterial effect of mango’s leaves (mangifera indica) extract against staphylococcus aureus and escherichia coli
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