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Veterinaria Medika

ISSN 1979-1305

Vol. 1 / No. 2 / Published : 2008-06

TOC : 11, and page :54 - 64

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Original Article :

The influence of 60% ethanol fraction and water fraction of justicia gendarussa burm.f leaf on pegion (columba livia) emetic activity

Author :

  1. Bambang Prajogo E.W.*1
  2. Ayun S.*2
  3. Soedjak N.*3
  1. Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi Universitas Airlangga
  2. Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi Universitas Airlangga
  3. Departemen Farmakolgi, Facultas Kedokteran Universitas Airlangga

Abstract :

According to the previous research on antifertility activity to spermatozoa of Justicia gendarussa Burm.f, it was found to be potentially developed as phytopharmacetical product for man antifertility. Hence, it must be followed by adverse drug reaction trials on Justicia gendarussa Burm.f usage. To know the adverse drug reaction which is arise because of Justicia gendarussa Burm f, it requires the emetic study. This study was done to recognize the safety level of Justicia gendarussa Burm f usage. The aim of this research was to observe the emetic effect of water fraction 0,9196 g/kgBW (1/17 LD50) dose and 1,3028 g/kgBW (1/12 LD50) dose; The free alkaloid 60% ethanol fraction on doses 0,23887 g/kgBW (1/75 LD50), 0,47773 g/kgBW (1/37 LD50), and 1.90194 g/kgBW (1/9 LD50); 1% solution of CuSO4 (100 mg/mL) as positive control; and negative control solution. These trial solutions were given to 7 groups of pigeon which contained 3 pigeon in each group. The pigeon’s body weight about 200-400 kg. Every group has been given the trial solution orally and then observed in glass box for 3 hours. The observations were done on emesis times and frecuentions. The results showed that the free-alkaloid 60% ethanol fraction 0,23887 g/kgBW and 0,47773 g/kgBW doses didn’t show emetic effect, while 1,90194 g/kgBW dose showed emetic effect with first emetic average time in 10th minute to pigeon. From the observation on the groups treated with the water fraction 0,9196 g/kgBW and 1,3028 g/kgBW doses showed emetic effect with first emetic average time at 75th and 122th minute respectively.

Keyword :

Water fraction, free-alkaloid 60% ethanol fraction, Justicia gendarussa Burm.f, Columba livia, alkaloid,


References :

  1. Anggorodi, R., (1985). Ilmu Makanan Ternak Unggas. Surabaya : Universitas Airlangga
  2. Boyd, M.E., (1971). Drill's Pharmacology In Medicine. . : Mc Graw Hill Book Company, Inc.


   


Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2008-06
  1. Prevalence rate of bovine mastitis from several dairy herds in east java
  2. The sambiloto leaf as an active subtance of dipping solution on a dairy cattle mastitis
  3. Protein characterization of insulin like growth factor – i complex of goat seminal plasma as an capacitation medium of sperm
  4. The influence of infected oocyst of eimeria tenella on meat quality of broilers
  5. Increasing yoghurt flavour dan texture from goats milk by adding inoculan consentration
  6. The sensitivity test of several antimicrobial agents to escherichia coli that caused mastitis in dairy cows at around of suka makmur dairy cooperative grati pasuruan
  7. Sex determination from mandible by angular morphometric methods on goat (capra spp.)
  8. Identification of protein growth differentiation factor-9 (gdf-9) isolated from oocytes dominant follicles of bovine ovum
  9. Effect of teratogenic insecticide carbofuran at chicken embryo
  10. The addition of heparin and hypotaurine in capacitation medium earle’s balanced salt solution (ebss) on embryo development in vitro fertilization of dairy cattle
  11. The influence of 60% ethanol fraction and water fraction of justicia gendarussa burm.f leaf on pegion (columba livia) emetic activity
  12. Biosynthesis and regulation of sex pheromones (z)-9-tricosene in the housefly, musca domestica
  13. Detection of rabbits serum antibody which were immunized by sarcoptes scabiei var. caprae