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Veterinaria Medika

ISSN 1979-1305

Vol. 9 / No. 3 / Published : 2016-11

TOC : 3, and page :15 - 22

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Original Article :

The influence of beta carotene to live fetus percentage in mice (mus musculus) that exposured by cigarette smoke

Author :

  1. Celica Alqurratu Rizqi*1
  2. Mas’ud Hariadi*2
  3. Sunaryo Hadi Warsito*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This research was conducted to observe the aplication of different doses of betacarotene toward live fetus percentage in mice (Mus musculus) that exposured by cigarretesmoke. Cigarrete smoke exposured during pregnancy can increase the levels of ReactiveOxygen Species (ROS) that disrupts the physiological maternal pregnancy and embryonicdevelopment. Beta carotene was able to reduce levels of ROS which act as antioxidants.This research was used 20 female matured mice and 20 male matured mice. Female micewere divided randomly into five groups and each got four repetitions. Each group wasused different dose. First group was negative control and used soya oil, second group waspositive control and used soya oil and one cigarette, third group was used beta carotene32,5 IU / 20 g BW in soya oil and one cigarrete, fourth group was used beta carotene 65IU / 20 g BW in soya oil and one cigarrete, fifth group was used beta carotene 130 IU / 20g BW in soya oil and one cigarrete. The experiment given per-orally of beta carotene andexposured cigarette smoke 6 – 15 pregnancy days. The data were analyzed using ANOVAand Duncan test. The result showed that aplication of beta caroten was significantlydifferent for live fetus in mice (P<0.05). Based on the research, the conclusion was thatthe oral administration of beta carotene can maintain live fetus percentage in pregnantmice (Mus musculus) that exposured by cigarette smoke.

Keyword :

Beta carotene, live fetus percentage, cigarrete smoke, ROS,

References :

  1. Afonso, V. and R. Champy., (2007). Reactive Oxygen Species and Superoxide Dismutases : Role in Joint Diseases.. 74: 324-329. : Science direct.
  2. Agarwal, A., S. Gupta and R. K. Sharma. , (2005). Role of Oxidative Stress in Female Reproduction. . 3 (28). : Reproductive Biology and Endocrinology.
  3. Amasha, H. A. dan M. S. Jaredah. , (2012). Effect of Active and Passive Smoking During Pregnancy on its Outcomes. . 6(2). : J. Health Science.


Archive Article

Cover Media Content

Volume : 9 / No. : 3 / Pub. : 2016-11
  1. The effect of spirulina platensis extract immersion as immunostimulant to intestine histopathology of aeromonas hydrophila infected gouramy (osphronemus gouramy)
  2. Effect of vitamin e and vitamin c combination as preventive measure on the leydig cell number in mice (mus musculus) treated with borax
  3. The influence of beta carotene to live fetus percentage in mice (mus musculus) that exposured by cigarette smoke
  4. Effects of vitamin c and vitamin e combinationas prevention on the liver histopathological in mice (mus musculus) treated with borax
  5. Effect of moringa oleifera leaf extract on the percentage of necrotic purkinje cells in mice (mus musculus) induced by methylmercury
  6. Hepatoprotective effect of andrographis paniculata ness. leaves extract towards mice (mus musculus l.) liver histopathology which exposured bylead acetate orally
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