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Veterinaria Medika

ISSN 1979-1305

Vol. 5 / No. 3 / Published : 2012-11

TOC : 8, and page :195 - 200

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Original Article :

The role of d-alpha tocopherol therapy to blood glucose levels and levels of mda (malondialdehyde) in diabetes mellitus type 1 rats by mld-stz

Author :

  1. Anita Herawati*1
  2. Aulanni’am*2
  3. Sasangka Prasetyawan*3
  1. Program Pascasarjana Bidang Minat Biokimia, Jurusan Kimia, Fakultas MIPA, Universitas Brawijaya, Malang, Indonesia
  2. Laboratorium Biokimia, Jurusan Kimia, Fakultas MIPA, Universitas Brawijaya, Malang, Indonesia
  3. Laboratorium Biokimia, Jurusan Kimia, Fakultas MIPA, Universitas Brawijaya, Malang, Indonesia

Abstract :

Diabetes Mellitus (DM) is a metabolic disorders, followed by the inflammatory process in the pancreatic tissue.Inflammatory process occurs due to an increase in free radicals. In this condition the body activate endogenous enzymatic antioxidants such as superoxide dismutase (SOD). Herbal therapy using bioactive that act as antioxidants has been widely studied for treating diabetes.Vitamin E (d-alpha tocopherol) is an antioxidant that will be tested antioxidant activity in lowering blood glucose levels and malondialdehyde levels in diabetic rats that induced by streptozotocin (STZ).In this study used an animal model of type 1 diabetes rats with multiple low-dose repeated (MLD-STZ) streptozotocin of 20 mg / kg for 5 consecutive days.Therapy d-α-tocopherol conducted with doses of 200 and 300 mg / kg every 2 days for 11 times.The results showed that d-α therapy-tocopherol at a dose of 200 and 300 mg / kg body weight in rats induced by MLD-STZ showed a decrease in blood glucose levels and MDA, respectively for 71.34%, 84.16%, and 41 , 16%, 69.51%, and repair damage to the pancreas tissue. d-α-tocopherol 300 mg / kgbody weight is the maximum dose in this study.

Keyword :

d-alfa tokoferol, Diabetes mellitus tipe 1, Streptozotocin, MDA, Blood glucose,


References :

  1. Begley T. P., R.M. Anthony, W.O. Bert, R. Lynn dan H..T.Jr. Armen, (2007). Vitamin E and Hormones. . : J. Elsevier : 76
  2. Debier, C. and Y. Larondelle, (2005). Vitamins A and E: Metabolism, Roles And Transfer to Offspring. . : DOI:10.1079/BJN 20041308
  3. Gawel S., M. Wardas, E. Niedworok and P. Wardas, (2004). Malondialdehyde (MDA) as a lipid peroxidation marker. . : Wiad Lek, 57(9-10): 453-55


   


Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2012-11
  1. Decrease of spermatozoa fertility rate and overview histopathologic seminiferous tubules of mice (mus musculus) with malnutrition conditions
  2. Antibacterial susceptibility of bacillus subtilis isolated from shrimp pond and fish pond sediment
  3. The efectivity of red rose flower(rosa damascena mill) extract as an antiseptic toward chronic stomatitis on phyton snake (python reticulatus)
  4. Potential rice bran fermented with enterobacter cloacae wpl 111 to the crude fiber disgestibility of broiler
  5. The decrease of progesterone-b receptor roles in abortion ewe by dexamethasone administration
  6. Antibiotic susceptibility pattern of staphylococcus aureus isolated from mastitis in dairy cattle at argopuro dairy cooperative in krucil probolinggo district
  7. Therapeutic effect of water extract leaf kedondong (lannea coromandelica) to levels of malondialdehyde (mda) and protease activity in ileum rat (rattus norvegicus) inflammatory bowel disease (ibd) induced by indomethacin
  8. The dynamic of maturation promoting factor (mpf) on cyprinus carpio oocytes after induced by artificial activation
  9. The role of d-alpha tocopherol therapy to blood glucose levels and levels of mda (malondialdehyde) in diabetes mellitus type 1 rats by mld-stz
  10. Oestrous decrease and ovarian histopathologic description of female mouse (mus musculus) with malnutrition condition
  11. Closed house method to influence of body weight, mortality rate and crop periode in broiler farm
  12. Insulin like growth factor-i complex sebagai alternatif antioksidan pada media pendewasaan spermatozoa kambing
  13. The effect of giving eugenia polyantha extract to liver histopathology on rattus norvegicus strain sprague dawley induced with dmba (dimetilbenz[a]antrasen)