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Folia Medica Indonesiana

ISSN : 0303-7932

Vol. 41 / No. 3 / Published : 2005-07

TOC : 1, and page :186 - 186

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Original Article :

EDITORIAL Vol 41 No 3 2005

EDITORIAL Vol 41 No 3 2005

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Abstract :

Psychological modulation of immune function is now a well-established phenomenon. Psychoneuroimmunology (PNI)provides a distinct perspective regarding the interrelatedness of the nervous, endocrine, and immune systems. PNIexplicates the possible means by which behavior and emotion can influence immune function. It embraces the scientificevidence of research with that of endocrinology, neurology and immunology, which shows that the brain and bodycommunicate with each other in a multidirectional flow of information that consists of hormones,neurotransmitters/neuropeptides, and cytokines. Moreover, PNI explains the means by which the immune systemaffects the nervous system and affects psychological response. The interactions among these systems are mediated atthe molecular level by cytokines and hormones produced by cells of not just the immune but also the nervous andendocrine systems. These cytokines and hormones affect endocrine and neuronal processes that, in turn, affect mood,emotions, personal perception, as well as the immune response. Recently, Robert Ader has stated thatimmunoregulation is not autonomous. This may substantially change the concept of immunology.Psychoneuroimmunology is an integrative paradigm for advancing both theoretical and empirical knowledge ofphysiological patterns that contribute to the dynamics of health. Advances in mind-body medicine research togetherwith healthy nutrition and lifestyle choices can have a significant impact on health maintenance and disease prevention.Furthermore, studies of interactions between the nervous and immune systems that effect immunological and behavioralchanges are also relevant to our understanding biological issues pertinent to evolution, etiology, ecology, and aging. It isknown that changes in maternal hormonal and immune function as a result of stress may adversely affect the immunefunction and neurodevelopment of the fetus. Recent data suggest that stress induced alterations in gastrointestinalinflammation may be mediated through changes in hypothalamic-pituitary-adrenal (HPA) axis function and alterationsin bacterial-mucosal interactions, and via mucosal mast cells and mediators such as corticotrophin releasing factor(CRF). There is evidence that psychologic stress constitutes an increased risk for atopy and influences the disease'sclinical course. This risk is believed mediated by the effects of stress on neuroimmunoregulation, which in turnmodulates the hypersensitivity response and involves immunoglobulin E-mediated inflammation, helper T-cell 2predominance, and eosinophilia.

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Archive Article

Cover Media Content

Volume : 41 / No. : 3 / Pub. : 2005-07
  1. Editorial Vol 41 No 3 2005
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  3. The Potency Of Piperine As Antiinflammatory And Analgesic In Rats And Mice
  4. Brain Derived Neurotrophic Factor (bdnf) Is A Key Mediator Of Learning Plasticity
  5. Migraine Headache In A Child With House Dust And Mite Allergy. A Case Report
  6. Long Versus Standard Initial Steroid Therapy For Children With Idiopathic Nephrotic Syndrome
  7. Research Article: The Effect Of Nursing Care Approach Model (ncam = Pakar) On The Increase Of Cd4 Cell Count For Patient With Hiv Infection
  8. Clinical Outcome Of Asthma With House Dust Immunotherapy In Children
  9. Different Clinical Manifestation Of Cerebral Lupus Due To Different Brain Involvement. A Report Of Two Cases
  10. A Comparative Test Of Eyedrops Timolol 0.5% And Betaxolol 0.5% In The Reduction Of Intraocular Pressure In Primary Open-angle Glaucoma In Dr Soetomo Hospital, Surabaya
  11. Efficacy Of Fine Needle Biopsy In The Diagnosis Of Tuberculous Cervical Lymphadenitis
  12. Molecular And Immunological Aspects Of Anemia In Malaria
  13. Review Article And Clinical Experience: Insulin Glargine Combined With Oral Agent In T2dm (clinical Uses Of Formulas: 1/3, 5-5, 2-2, 1-1, And 1-2)