UNIVERSITAS AIRLANGGA



Detail Article

Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 2 / No. 1 / Published : 2013-06

Order : 6, and page :32 - 39

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Original Article :

Aktivitas antinociceptiv dan uji in silico terhadap cyclooxygenase dari asam p-metoksisinamat dan asam m-metoksisinamat

Author :

  1. Juni Ekowati*1
  2. Nuzul W.Diyah*2
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi

Abstract :

The object of this study was to prove antinociceptive activity of p-methoxycinnamic acid and m-methoxycinnamic acid by writhing test method and their in silico test againts cyclooxygenase (COX-1 PDB ID = 1PTH; COX-2 PDB ID = 1CX2) using Molegro computer programme ver 5.5. The results showed that both of test compounts have antinociceptive activity which are dose dependent. The antinociceptive potential of the both compounds are higher than acetyl salicylic acid. The results of in silico test showed affinity of APMS and AMMS against COX-1 and COX-2 are better than acetyl salicylic acid.    

Keyword :

p-methoxycinnamic acid, m-methoxycinnamic acid, writhing test, antinociceptive, cyclooxygenase,


References :

Adinarayana, K.P.S., Reddy, P.A., Babu, P.A. ,(2012) Structural Studies on Docking Selective COX-2 Inhibitors Journal : J. of Bioinformatics & Research 1(1)

Ali G., Subhan F., Wadood A., Khan A., Ullah N., Ul Islam N., Khan ,(2013) Pharmacological evaluation, molecular docking and dinamics simulation studies of salicyl alcohol nitrogen containing derivatives Journal : African J. of Pharmacy and Pharmacology

Ekowati, J., Suzana, Budiati, T. ,(2005) Pengaruh Posisi Gugus Metoksi para dan meta terhadap hasil Sintesis asam p-metoksisinamat dan asam m-metoksisinamat Journal : Airlangga J. of Pharmacy





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-06
  1. Validasi Spektrofotometri Visible Untuk Penentuan Kadar Formalin Dalam Daging Ayam
  2. Validasi Metode Kromatografi Gas-spektrometri Massa Untuk Penetapan Kadar Residu Endosulfan Dalam Kubis
  3. Sintesis Dan Uji Aktivitas Antikanker Senyawa 1-(2-klorobenzoiloksi)urea Dan 1-(4-klorobenzoiloksi)urea
  4. Pengaruh Gugus Metoksi Posisi Orto (o) Dan Para (p) Pada Benzaldehida Terhadap Sintesis Turunan Khalkon Dengan Metode Kondensasi Aldol
  5. Modifikasi Struktur N-fenilurea Menjadi Senyawa Baru N-benzoilfenilurea Dan 4-fluorobenzoilfenilurea Serta Uji Aktivitasnya Sebagai Penekan Susunan Saraf Pusat
  6. Aktivitas Antinociceptiv Dan Uji In Silico Terhadap Cyclooxygenase Dari Asam P-metoksisinamat Dan Asam M-metoksisinamat
  7. Docking Dan Modifikasi Struktur Senyawa Baru Turunan Parasetamol

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