Berkala Ilmiah Kimia Farmasi
ISSN 2302-8270
Vol. 1 / No. 1 / Published : 2012-11
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Original Article :
Pembuatan dan karakterisasi elektrode selektif ion (esi) salbutamol berbasis membran tipe kawat terlapis
Author :
- Riesta Primaharinastiti*1
- Departemen Kimia Farmasi Fakultas Farmasi Universitas airlangga
Abstract :
A graphite coated-wire Salbutamol Ion Selective Electrode (ISE) based on ion associate of salbutamolium phosphotungstate (Sl-PTA) in a polyvinyl chloride (PVC) matrix was developed. An optimum mixture of PVC, DOP as plasticizer and Sl-PTA as ion pairing agent (47.5 %: 47.5 %: 5.0 %) was used in preparing the coatings. Prior to measurements, the salbutamol selective electrode was characterized in its linearity, Nernstian factor, sensitivity, response time, life time and selectivity coefficient. The graphite coated-wire ISE exhibited a linear Nernstian over the range 10-1 to 4.10-5 M with slope of 58.68 mV per decade change and response time less than 1 minute. The detection limit of electrode was 4.10-5 M. The electrodes showed good selectivity to salbutamolium ion in present of Na (I), K (I) and Mg (II) ions.
Keyword :
salbutamol, ion selective electrode, graphite coated-wire,
References :
Departemen Kesehatan Republik Indonesia,(1995) Farmakope Indonesia Edisi IV Jakarta : Farmakope Indonesia Edisi IV
Buchari,(1990) Analisis Instrumentasi Bagian I : Tinjauan Umum dan Analisis Elektrometri Bandung : Jurusan Kimia ITB
Atikah,(1994) Pembuatan dan Karakterisasi ESI Nitrat Tipe Kawat Terlapis Bandung : Tesis Magister Kimia ITB
Taylor, RF; Jerome S Schultz,(1996) Handbook of Chemical and Biological Sensors Philadelphia : Institute of Physics Publishing
Bailey, P.L,(1983) Analysis with Ion Selective - Electrodes London : Heyden & Sons Ltd
Archive Article
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