UNIVERSITAS AIRLANGGA



Detail Article

Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 2 / No. 1 / Published : 2013-06

Order : 4, and page :22 - 26

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Original Article :

Pengaruh gugus metoksi posisi orto (o) dan para (p) pada benzaldehida terhadap sintesis turunan khalkon dengan metode kondensasi aldol

Author :

  1. Suzana*1
  2. Melanny Ika. S*2
  3. Kholis Amalia N*3
  4. Juni Ekowati*4
  5. Marcellino Rudyanto*5
  6. Hadi Poerwono *6
  7. Tutuk Budiati*7
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Dosen Fakultas Farmasi
  5. Dosen Fakultas Farmasi
  6. Dosen Fakultas Farmasi
  7. Dosen Fakultas Farmasi

Abstract :

The purpose of this research was cognizant of the influence of orto and para methoxy groups on benzaldehyde in synthesis of  2-methoxychalcone and 4-methoxychalcone. Synthesis was done  with aldol condensation using NaOH 50% as catalyst in room temperature for one hour. Orto and para methoxy groups on benzaldehyde had influence by enhancing the reactivity C carbonyl benzaldehyde, that build the carbonyl positive center faster.  Chalcone was determined as yellow crystal (66,4%), melting point 53-54 oC, 2-methoxychalcone was yellow crystal (75,9%), m.p. 58-59oC, and yield of 4-methoxychalcone was 85,2%, m.p. 73-74 oC. Compounds identification using UV-Vis, Infrared and 1H-NMR spectroscopy.      

Keyword :

Synthesis, methoxy groups, aldol condensation, chalcone derivatives,


References :

Jayapal, MR.; Prasad, K.S. and Sreedhar, N.Y. ,(2010) Synthesis and Characterization of 2,6-Dihydroxy Substituted Chalcones Using PEG-400 as a Recyclable Solvent Journal : J. Pharm. Sci. & Res. Vol.2 (8)

Silverstein RM., Webster FX., Kiemle DJ.,(2005) Spectromeric Identification of Organic Compound New York : John Willey and Sons Inc





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-06
  1. Validasi Spektrofotometri Visible Untuk Penentuan Kadar Formalin Dalam Daging Ayam
  2. Validasi Metode Kromatografi Gas-spektrometri Massa Untuk Penetapan Kadar Residu Endosulfan Dalam Kubis
  3. Sintesis Dan Uji Aktivitas Antikanker Senyawa 1-(2-klorobenzoiloksi)urea Dan 1-(4-klorobenzoiloksi)urea
  4. Pengaruh Gugus Metoksi Posisi Orto (o) Dan Para (p) Pada Benzaldehida Terhadap Sintesis Turunan Khalkon Dengan Metode Kondensasi Aldol
  5. Modifikasi Struktur N-fenilurea Menjadi Senyawa Baru N-benzoilfenilurea Dan 4-fluorobenzoilfenilurea Serta Uji Aktivitasnya Sebagai Penekan Susunan Saraf Pusat
  6. Aktivitas Antinociceptiv Dan Uji In Silico Terhadap Cyclooxygenase Dari Asam P-metoksisinamat Dan Asam M-metoksisinamat
  7. Docking Dan Modifikasi Struktur Senyawa Baru Turunan Parasetamol

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