The Indonesian Journal of Public Health
ISSN 1829-7005
Vol. 10 / No. 1 / Published : 2013-07
Order : 7, and page :70 - 76
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Original Article :
The effects of organophosphate pesticides exposure to liver function and cholinesterase serum activity among apple growers applying pesticides
Author :
- Iwan Desimal*1
- Jojok Mukono*2
- Mahasiswa Fakultas Kesehatan Masyarakat
- Dosen Fakultas Kesehatan Masyarakat
Abstract :
Organophosphate pesticides are the most commonly used insecticides in developing country such as Indonesia. The research location is the center of apple plantation from which its title the City of Apple originated. The use of pesticides can harm one’s health, for instance inhibiting serum cholinesterase activities and impairs liver function in the long run. Diagnosis administered to detect liver damage is liver function test (LFTs) which measures elevated liver enzymes indicating liver damage like Serum Glutamic Pyruvic Transaminase (SGPT), Alkaline Phosphatase (ALP), Gamma Glutamic Tranferase (GGT). The research aims to analyze the effects of organophosphate pesticides exposures on cholinesterase serum activity as well as liver function among apple growers who work with pesticides. The research is an observational study using cross sectional approach. A total of 40 samples were sorted into two groups, 20 samples were exposed to pesticides while the other 20 samples were not exposed to pesticides. The samples were then analyzed using multi linear regression technique. The result shows a correlation between the use of improper dose of pesticides and cholinesterase activity (p < 0.05). Liver function test (LFTs) shows a correlation between pesticides dose and spraying frequency and the activity of Serum Glutamic Pyruvic Transaminase/SGPT (p < 0.5). Higher dose and variety of the pesticides’ types shall lower the cholinesterase serum activity. The conclusion show that the dose, type of poisoning, and hours of exposure can raise enzymes activity indicating liver function damage. Consequently, need of more supervision and technical guidance from the Agriculture Office as well as Health Office on the safe procedure of pesticides. The importance of the package’s label before its use and the use of protective clothing and equipment (PCE).
Keyword :
organophosphate, pesticides exposure, cholinesterase serum, liver function and pesticides sprayer,
References :
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Lubis H.S,(2002) Deteksi Dini
Archive Article
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 Volume : 10 / No. : 1 / Pub. : 2013-07 |
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