UNIVERSITAS AIRLANGGA



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Jurnal Farmasi dan Ilmu Kefarmasian

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Vol. 1 / No. 2 / Published : 2014-12

Order : 2, and page :36 - 41

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Original Article :

Permasalahan terkait obat antihipertensi pada pasien usia lanjut di poli geriatri rsud dr.soetomo, surabaya

Author :

  1. Budi Suprapti*1
  2. Wenny Putri Nilamsari*2
  3. Pharmasinta Putri Hapsari*3
  4. Husna Arifatul Muzayana*4
  5. Hadiq Firdausi*5
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi
  4. Departemen Ilmu Penyakit Dalam, RSUD Dr. Soetomo Surabaya
  5. Departemen Ilmu Penyakit Dalam, RSUD Dr. Soetomo Surabaya

Abstract :

Backgrounds. High prevalence of multidrug use combined with age-related alteration of pharmacokinetic and pharmacodynamics makes elderly hypertensive patients vulnerable to drug related problems (DRPs). The objective of this study was to identify the usage pattern and both actual and potential DRPs of anti-hypertension therapy in geriatric patients. Method. A prospective observational study was conducted in Geriatric Ambulatory Station, Dr. Soetomo Hospital – Surabaya from March to May 2012. The demographic data of hypertensive patients was collected by reviewing the patient’s medical record. Analysis of  drug side effect was done by interviewing  the patients and others DRP by reviewing the drugs and patients condition, and literature reviews     Result. From 350 samples showed that hypertension was most commonly found in “young old” group (66-74 years old) (50.9%). More than half of the patients had diabetes mellitus as comorbid. More than 60% of the patients received more than one anti-hypertension therapy. ARB, CCB, and ACEI were three most frequent used drugs. Actual and potential DRPs were identified in 3.2% and 62% cases: inappropriate drug of choice (1.4%), inappropriate dose and frequency (0.3%), side effects (2.1%), and potential non-benefited drug interaction (62.0%), whereas one patient could have more than one problem. More than two third of the patients could not achieve the target blood pressure according the JNC VII and AHA recommendations. Conclusion. Management of hypertension in geriatric patients still left unresolved preventable DRPs.

Keyword :

anti-hypertension, geriatric patient, drug related problems,


References :

Fitriah N,(2006) Hubungan Kebiasaan Makan Masa Lalu dengan Kejadian Hipertensi pada Lansia (Studi Kasus di RSU Dr. Soetomo Surabaya) Surabaya : Health Science Journal

Neal,(2005) At a Glance Farmakologi Medis Edisi Kelima Jakarta : Penerbit Erlangga

Apoeso OA. Hypertension,(2007) In: Soriano RP, Fernandez HM, Cassel CK, Leipzig RM (Eds.) Fundamental of Geriatric Medicine:A Case-Based Approach New York : Springer

Nawrot T, Hond ED, Thijs L, Staessen JA,(2005) Blood Pressure and Aging. In: Hypertension Principles and Practice USA : Taylor & Francis Group

Shorr et al,(2007) Drugs for the Geriatric Patient Philadelphia : Saunders Elsevier Inc





Archive Article

Cover Media Content

Volume : 1 / No. : 2 / Pub. : 2014-12
  1. Evaluasi Mutu Pelayanan Di Apotek Komunitas Kota Kendari Berdasarkan Standar Pelayanan Kefarmasian
  2. Permasalahan Terkait Obat Antihipertensi Pada Pasien Usia Lanjut Di Poli Geriatri Rsud Dr.soetomo, Surabaya
  3. Studi In Silico Gendarusin A, B, C, D, Dan E Untuk Prediksi Absorbsi Dan Aktivitas Terhadap Hialuronidase (ec 3.2.1.35)
  4. Pengaruh Sistem Miroemulsi Tipe W/o Terhadap Karakteristik Sediaan Dan Pelepasan Natrium Diklofenak (perbandingan Konsentrasi Surfaktan (span 80-tween 80): Kosurfaktan (etanol 96%) = 6:1 Dalam Basis Gel Hpmc 4000)
  5. Efek Apoptosis Ekstrak Etanol Ganggang Hijau (spirogyra Sp.) Terhadap Ekspresi Caspase-3 Dan Bcl-2 Pada Sel T47d
  6. Perbandingan Aktivitas Antioksidan Ekstrak Aseton Tomat Segar Dan Pasta Tomat Terhadap 1,1-diphenyl-2-picrylhidrazyl (dpph)
  7. Uji Aktivitas Ekstrak Biji Sirsak (annona Muricata L.) Terhadap Sel Kanker Mamalia Secara In Vitro

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