UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 2 / No. 2 / Published : 2015-12

Order : 4, and page :48 - 52

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Original Article :

Potensi antimalaria dan pemeriksaan mikroskopik-fitokima daun beberapa tanaman genus cassia

Author :

  1. Wiwied Ekasari*1
  2. Tutik Sri W *2
  3. Ratno Adji Satyo Y*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Departemen Farmakognosi dan Fitokimia, Fakultas Farmasi Universitas Airlangga

Abstract :

This research was done to determine the anti-malarial activity in vitro and in vivo of leaves of some plants from the Cassia genus. In addition to support studies of Chemotaxonomic this genus, phytochemical and microscopic investigation of each of these leaves was done too. Towards leaf that has the largest antimalarial activity was continued  in vivo antimalarial test. The results showed that the methanol extract of leaves of C. spectabilis has the strongest antimalarial activity against Plasmodium falciparum in vitro with IC50 of 2.66ug/mL, and inhibits the growth of the rodent malaria parasite Plasmodium berghei in vivo at  59, 29% (at a dose of 100mg/kg BB). Microscopic and phytochemical identification generally showed similarities,  but only the leaves of C. spectabilis which shows that it contains alkaloids, while  on the other cassia plants are not detected.

Keyword :

Cassia, anti-malarial, in vitro, in vivo, Chemotaxonomic,


References :

Ekasari W. and Widyawaruyanti A.,(2004) Uji antimalaria Senyawa Hasil Isolasi Fraksi Positif Alkaloid Daun Cassia Siamea Pada Biakan in Vitro Plasmodium Falciparum Surabaya : Universitas Airlangga

Markus M.,(2006) Isolasi Dan Uji Aktivitas Antimalaria Ekstrak Metanol, Fraksi Dan Isolat-Isolat Dari Kulit Batang Cempedak (Artocarpus champeden Spreng) Surabya : Universitas Airlangga

Munoz V, Sauvin M, Bourdy G, Callapa J, Rojas I, Vargas L, Tae A, Deahro E.,(2000) The search for natural bioactive compounds through a multidisciplinary approach in Bolivia. Part II. Antimalarial activity of some plants used by Mosetene Indians Vol 69. pp.139-155 : J.Ethnopharmacology

Weenen H; Nkunya M.H.H; Bray D.H; Mwasumbi L.B.; Kinabo L.S; Kilimali A.E.B.,(1990) Antimalarial Activity of Tanzanian Medicinal Plants 56:368-370 : J. Planta Medica

Trager, W.and Jensen, J.B.,(1976) Human Malaria parasites in continous culture 193, pp. 673-676 : Science





Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2015-12
  1. Aktivitas Antivirus Influenza Dari Ekstrak Metanol Buah Momordica Charantia
  2. Identifikasi Golongan Senyawa Dan Uji Toksisitas Akut Ekstrak Etanol 95 Persen Daun, Kulit Batang Dan Akar Pulai (alstonia Scholaris (l.) R. Br.) Terhadap Mencit Balb/c
  3. Aktivitas Antibakteri Kombinasi Susu Probiotik Lactobacillus Bulgaricus Dan Streptococcus Thermophilus Terhadap Bakteri Penyebab Diare
  4. Potensi Antimalaria Dan Pemeriksaan Mikroskopik-fitokima Daun Beberapa Tanaman Genus Cassia
  5. Optimasi Campuran Manitol - Pemanis Stevia Sebagai Pemanis Tablet Kunyah Ekstrak Jahe Merah (zingiber Officinale Roscoe Var.rubrum) Dengan Metode Simplex Lattice Design
  6. Efek Apoptosis Ekstrak Etanol Ganggang Hijau (ulva Lactuca) Pada Jantung Tikus Yang Diinduksi Isoproterenol
  7. The Effect Of Anting-anting (acalypha Indica Linn) Extract With Malondialdehyde Levels Of Balb/c Mice Induced Streptozotocin

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