Berkala Ilmiah Kimia Farmasi
ISSN 2302-8270
Vol. 2 / No. 2 / Published : 2013-11
Order : 7, and page :37 - 42
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Original Article :
Perbandingan aktivitas penekan susunan saraf pusat senyawa baru n-benzoilfenilurea dan 4-nitrobenzoilfenilurea
Author :
- Bambang Tri Purwanto*1
- Dosen Fakultas Farmasi
Abstract :
Activity test of the central nervous system and synthesis from he new compound N-benzoylphenilurea and 4-nitrobenzoylphenylurea has been done. The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride derivatives. The CNS depressant activity test was done for the N-benzoylphenylura compound and 4-nitrobenzoylphenylurea by Barbituric Sleeping Time (BST) method. The yield of the N-benzoilphenylurea was 86% , had a white crystal , the 4-nitrobenzoylphenylurea was a yellow brown crystal and yield was 65%. Both of them gave one spot in Thin Layer Chromatography with two different eluent and the compounds melting point was different from the N-phenylurea and showed greater. The structure identification from the all novel compounds were analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound were N-benzoylphenylurea and 4-nitrobenzoylphenylurea . The CNS depressant activity test from N-benzoylphenylurea and 4-nitrobenzoylphenylurea had a greater activity if compare with the standard compound bromisoval.
Keyword :
N-benzoylphenilurea and 4-nitrobenzoylphenylurea, CNS depressant activity,
References :
Achliya GS, Wadodkar SG, Dorle AK ,(2005) Evaluation of CNS activity of Bramhi Ghrita, Journal : Indian Journal of Pharmacology
Archive Article
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 Volume : 2 / No. : 2 / Pub. : 2013-11 |
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