UNIVERSITAS AIRLANGGA



Detail Article

Berkala Ilmiah Kimia Farmasi

ISSN 2302-8270

Vol. 4 / No. 1 / Published : 2015-06

Order : 2, and page :8 - 11

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Original Article :

Sintesis n’-benzilidenbenzohidrazida dan n’-(4-metoksibenziliden)-benzohidrazida dengan material awal metilbenzoat

Author :

  1. Suzana*1
  2. ERLINA ARDHAYANTI*2
  3. Tutuk Budiati*3
  1. Dosen Fakultas Farmasi
  2. Mahasiswa Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

The synthesis of N'-benzylidenebenzohydrazide and N'-(4-methoxybenzylidene)benzo hydrazide had performed through condensation reaction. The reaction was performed in two stages with methylbenzoate as the initial material. The first phase was obtained benzohydrazide  by reacting  methylbenzoate and hydrazine hydrate, the second phase was obtained the compound of N'-benzylidenebenzohydrazide and N '- (4-methoxyibenzylidene)benzohydrazide by reacting benzohydrazide and benzaldehyde/4-methoxybenzaldehyde. The results were obtained respectively  87% and 92%. Purity test was done by thin layer chromatography (TLC) and melting point. The melting point of benzohydrazide was 108-111oC. N'-benzylidene benzohydrazide m.p. 104-108oC  and N'-(4-methoxybenzylidene)benzohydrazide m.p. 159-161oC. Identifications synthesized were confirmed  by UV-VIS, FT-IR and 1H-NMR spectroscopy.     

Keyword :

Synthesis, N'-benzylidenebenzohydrazide, N’- (4-methoxybenzylidene)benzohydrazide, methylbenzoate,


References :

Jain AK, Gupta PK, Ganesan K, Pande A, Malhotra RC,(2007) Rapid solvent free Synthesis of Aromatic Hydrazides under Microwave Irradiation Journal : Defence Science Journal Vol.57(2





Archive Article

Cover Media Content

Volume : 4 / No. : 1 / Pub. : 2015-06
  1. Pengaruh Pasta Tomat (lycopersicon Esculentum Mill.) Pada Daya Hambat Lactobacillus Acidophilus Fncc-0051 Dan Lactobacillus Plantarum Fncc-0027 Terhadap Candida Albicans
  2. Sintesis N’-benzilidenbenzohidrazida Dan N’-(4-metoksibenziliden)-benzohidrazida Dengan Material Awal Metilbenzoat
  3. Validasi Metode Ekstraksi Quechers Untuk Analisis Multiresidu Pestisida Pada Wortel Secara Kromatografi Gas-spektrometri Massa
  4. Profil Bioautogram Bakteriosin Dalam Sediaan Susu Probiotik
  5. Aktifitas Antimikroba Fraksi-fraksi Dari Ekstrak Etil Asetat Jamur Endofit Yang Diisolasi Dari Aglaia Odorata Lour.
  6. Modifikasi Struktur Dan Prediksi Aktivitas Antikanker Senyawa Baru Turunan Aliltiourea Secara In Silico
  7. Penapisan Aktivitas Antioksidan Kombinasi Yogurt Dan Jus Tomat Dibandingkan Vitamin C

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