UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 1 / Published : 2009-01

Order : 10, and page :50 - 55

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Original Article :

Antiseizure and neurotoxicity effects of ligustrosid glycoside isolated from fraxinus graffithii clarke compared to phenytoin and diazepam

Author :

  1. Achmad Basori*1
  1. Department of Pharmacology, Faculty of Medicine, Airlangga University, Jl. Prof Dr Moestopo 47, Surabaya

Abstract :

A study was conducted to determine antiseizure and neurotoxicity effects of Ligustrosid (A CNS Active substance) isolated from Fraxinus Graffithii Clarke compared to Phenytoin and Diazepam (antiseizure standard). Phenytoin has only Anti MES effect. Diazepam has anti MES, anti Metrazol, anti Strychnine, anti Bicuculline, and anti INH effect. Ligustrosid has anti MES,anti Metrazol, anti Strychnine, anti Bicuculline, and anti INH effect. Therefore Ligustrosid has broad spectrum of antiseizure effects than Phenytoin and Diazepam. Clinically, it may be predicted that Ligustrosid will have clinical efficacy against various seizure type. i.e.Generalized Tonic Clonic, Partial seizure, Myoclonic seizure, Absence seizure, and Status epilepticus. Neurotoxicity study proved that Ligustrosid has minimum neurological deficit and other motoric disturbances (TD 50 neurotoxicity = 1413.63 mg/BW). This dosage is much higher than antiseizure activity dosage of Ligustrosid (290-466 mg/kg, BW i.p).Finally it is concluded that Ligustrosid was antiseizure candidate with no neurological deficit effect.

Keyword :

antiseizure, neurotoxicity, ligustrosid, phenytoin, diazepam,


References :

Swinyard, EA et al,(1989) Experimental Selection, Quantification, and Evaluation of Anticonvulsants, In : Antiepileptic Drugs, edited by Levy, RH dkk, 3th edition NY : Raven Press

White,HS et al,(1995) Experimental Selection, Quantification, and Evaluation of Antiepileptic Drugs, In: Antiepileptic Drugs, 4th edition, edited byRene.H.Levy et al NY : raven Press





Archive Article

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Volume : 45 / No. : 1 / Pub. : 2009-01
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  2. The Effectiveness Of Acid Phosphatase And Zinc Tests On The Seminal Fluid Spot Examination As The Primary Identification. A Laboratory Observational Study
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  4. Immuno-modulatory Effect Of Probiotic And Sublingual Immunotherapy In Asthmatic Children
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  8. Hyaluronan, Tnf-α And Estradiol Concentrations In Infertile Women With Endometriosis
  9. Factors Affecting Compliance To Medication In Lung Tuberculosis Patients
  10. Antiseizure And Neurotoxicity Effects Of Ligustrosid Glycoside Isolated From Fraxinus Graffithii Clarke Compared To Phenytoin And Diazepam
  11. Effect Of Andrographis Paniculata Extract On Mammary Carcinoma In Rats Induced By Dmba
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