UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 1 / Published : 2008-01

Order : 11, and page :52 - 55

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Original Article :

Bone morphogenetic protein 4 (bmp4) and prostaglandin alpha (pge2α) molecular expression in healing process acceleration of long bone shaft fracture using immediate repetitive axial compression tension stabilization (ireact)

Author :

  1. Achmad Sjarwani*1
  1. Department of Orthopaedics, Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Jl Prof Dr Moestopo 6-8, Surabaya

Abstract :

Bone morphogenic proteins (BMPs) play central roles in differentiation, development, and physiologic tissue remodeling. Prostaglandins are potent regulators of bone formation and bone resorption that can have both stimulatory and inhibitory effects. Here we present a novel mechanism for the inhibitory effect of estrogens on BMP2 function on acceleration of healing Process of long bone shaft fracture by Immediate Repetitive Axial Compression Tension Stabilization (IREACT). Male adult goats (fractured, Reposition-fixation, IREACT), 6 months of age were used in the study. Bone Morphogenetic Protein 4 (BMP 4) and that PGE2 were determined by immunohistochemistry technique and ELISA. Sample research are bone tissue and plasma that prepared from immediate and repetitive loading (IREACTS) compared to fracture without loading. The result showed that healing process occur more rapidly on immediate and repetitive loading (IREACTS) compared to fracture without loading based on the expression of BMP-4 and that PGE2 of bone tissues and serum. In this studies resulted that PGE2 have been shown to inhibit osteoblasts by repressing BMP 4 production. The result also indicated that prostaglandins are involved in the response of bone tissue and cells to mechanical stress. In conclusion, ER and BMP-4 have key roles in the mechanism to achieve bone healing.

Keyword :

IREACT, PGE2 , BMP-4,


References :

Jee, WS & Ma, YF,(1997) In vivo anabolic actions of prostaglandins in bone - : Bone (NY)

Keila, S, Kelner, A, Weinreb, M,(2001) Systemic prostaglandin E2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro - : J Endocrinol





Archive Article

Cover Media Content

Volume : 44 / No. : 1 / Pub. : 2008-01
  1. Correlation Between Dengue Virus Serotype And Humoral Immune Response In Pediatric Dengue Hemorrhagic Fever
  2. Modulation Of Immunoglobulin G (igg) And Cortisol Responses In Breathing Exercise
  3. Prediction Of Distribution Pattern Of Aedes Aegypti As Dhf Main Vector In Jember
  4. Difference Of Interferon Gammalevel (release Assay) In Nurses Exposed To Mycobacterium Tuberculosis And Active Tuberculous Patients
  5. Molecular Expression Of Estrogen Receptor Alpha (erα) And Interleukin 6 (il-6) On Acceleration Of Healing Process Of Long Bone Shaft Fracture By Immediate Repetitive Axial Compression Tension Stabilization (ireact)
  6. Il-4 In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Patients With Pulmonary Tuberculosis Before And After Treatment With Oral Anti-tuberculosis Drugs
  7. Effect Of Oral Curcumin And Immobilization On The Diameter Of Skeletal Muscle Fiber In Rattus Norvegicus
  8. Contralateral Renal Fibroblast And Tubular Cell Apoptosis And Proliferation In Artificial Unilateral Total Urethral Obstruction In Rabbits
  9. Polymorphism C3435t Of The Mdr-1 Gene Predicts Response To Preoperative Chemotherapy In Locally Advanced Breast Cancer With Her2/neu Expression
  10. Review Article:challenge Of Environmental Toxicology In Reformation Era
  11. Bone Morphogenetic Protein 4 (bmp4) And Prostaglandin Alpha (pge2α) Molecular Expression In Healing Process Acceleration Of Long Bone Shaft Fracture Using Immediate Repetitive Axial Compression Tension Stabilization (ireact)
  12. Treatment Response Of Chronic Myelogenic Leukemia In Dr. Soetomo Hospital
  13. Review Article And Clinical Experience:the Obesity Pandemic: The “time-bomb Disease” In The Future?where Have We Been? And What Should We Do?

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