UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 41 / No. 2 / Published : 2005-04

Order : 9, and page :130 - 137

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Original Article :

Brain natriuretic peptide as an indicator of left ventricle dysfunction and a predictor of cardiovascular events in acute coronary syndromes

Author :

  1. Nugroho *1
  2. M. Yogiarto*2
  1. Department of Cardiology Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Cardiology Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Background: Acute coronary syndromes can cause systolic and diastolic left ventricle (LV) dysfunction. Determination of LV dysfunction in ACS provides benefit to stratification and optimizing therapy. Brain Natriuretic Peptide (BNP) is secreted primarily from and synthesized in left ventricle in response to increased myocardial stretch. BNP increase in heart failure. BNP increase in the 24 hours in acute myocardial infarction. We hypothesized that BNP level could be as an indicator of systolic and diastolic dysfunction and a predictor of cardiovascular events in acute coronary syndromes. Objective: To investigate plasma level of BNP in systolic and diastolic dysfunction in acute coronary syndromes hospitalized to ICCU. To investigate plasma level of BNP as a predictor of cardiovascular events in acute coronary syndromes. Method and Result: We measured BNP in plasma specimen obtained 3 days after the onset of ischemic symptoms in 25 patients of acute coronary syndromes and prospectively followed the patients for 30 days. Patients diagnosed with evidence of systolic LV dysfunction had a mean BNP concentration of 301.11 ± 189.62 pg/ml, higher than those patients with normal LV function (42.67 ± 22.44 pg/ml, p = 0.003). Patients diagnosed with evidence of diastolic LV dysfunction had a mean BNP concentration of 273.70 ± 146.27 pg/ml, higher than those patients with normal LV function (42.67 ± 22.44 pg/ml, p = 0.006). Patients with cardiovascular events had a mean BNP concentration of 392.30 ± 157.14 pg/ml, higher than patients without cardiovascular events (118.67 ± 78.53 pg/ml, p < 0.0001). In patients with cardiovascular events, minimum plasma BNP level (248 pg/ml) was higher than maximum plasma BNP level in patients without cardiovascular events (234 pg/mL). Conclusion: Plasma BNP level can reliably detect the presence of diastolic or systolic LV dysfunction on echocardiography in acute coronary syndromes. Moreover, plasma BNP level can also predict patients with cardiovascular events in 30-days after acute coronary syndromes.

Keyword :

BNP, Left ventricle dysfunction, cardiovascular events, acute coronary syndromes,


References :

Daly-Nee C, Brunt H, Jairath N,(1999) Risk and Coronary Heart Disease. In Jairath N (Ed). Coronary Heart Disease & Risk Factor Management, 9th ed Philadelpia : WB Saunders Company

Nagaya N, Nishikimi T, Goto Y et al,(1998) Plasma Brain Natriuretic Peptide is a Biochemical Marker for the Prediction of Progressive Ventricular Remodeling After Acute Myocardial Infarction - : American Heart Journal





Archive Article

Cover Media Content

Volume : 41 / No. : 2 / Pub. : 2005-04
  1. Editorial Vol 41 No 2 2005
  2. Opinion: Bioethics. Its Role In Research
  3. Gastroprotective Effect Of Curcumine On Ethanol-induced Gastric Mucosal Lesions In Rats
  4. Spermatozoa Motility And Morphological Recovery Process In Mice (mus Musculus) After The Induction Of 2-methoxyethanol
  5. Nutritional And Immune Effects Of Early Enteral Feeding Supplemented By Arginine, Glutamine And Omega 3 Fatty Acid In Critically Ill Patients
  6. The Comparison Of The Effectiveness Between 2.5% Povidone-iodine Eye Drop And 1% Tetracycline Eye Ointment On Bacterial Ophthalmia Neonatorum Prophylaxis
  7. The Effectiveness Test Of Eyedrop Lodoxamide Tromethamine 0.1 % And Sodium Cromoglycate 2% In Vernal Keratoconjunctivity In Dr. Soetomo Hospital, Surabaya
  8. Risk Factors Of Symptomatic And Asymptomatic Osteoarthritis Of The Knee
  9. Brain Natriuretic Peptide As An Indicator Of Left Ventricle Dysfunction And A Predictor Of Cardiovascular Events In Acute Coronary Syndromes
  10. Management Of Perioperative Pulmonary Edema In Patient With Pre-eclampsia/eclampsia Undergoing C-section
  11. Water Source As The Risk Factor Of H. Pylori Infection In Chidren Aged 0 - 5 Years In Suburban Area Of Surakarta
  12. Clinical–epidemiological Data On Hiv/aids Patients Admitted To A Top Referral Hospital During 1997-2005. A Database For Action In The Future, Referring To Another Developing Countries
  13. Review Article And Clinical Experience: New Insights Into Oral Agents In The Treatment Of T2dm (the Roles Of Fixed-dose Oral Agents Combination)
  14. Literature Review: Choosing A Prosthetic Heart Valve

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