UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

Order : 4, and page :16 - 21

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Original Article :

Cardiac stress marker nt-probnp as an indicator of changes in cardiac function post percutaneous coronary intervention

Author :

  1. Hastrianna Dwi Septiade*1
  2. Siti Sjamsiah*2
  3. Mohammad Yogiarto*3
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Kedokteran

Abstract :

NT-proBNP is an amino terminal fragment of prohormone BNP released when there is cardiac wall stretch due to volume overload.The increase in NT-proBNP associated with the severity of heart failure and left ventricular ejection fraction. PCI can be improvedcardiac function of patients with CHD who indicated an increase in ejection fraction. The purpose of this study to analyze changes inNT-proBNP levels and ejection fraction, and analyze correlation between ejection fraction as an indicator of cardiac function andNT-proBNP as cardiac stress marker in CHD patients undergoing PCI. An observational cross sectional study was conducted toanalyze NT-proBNP levels and ejection fraction in patients with coronary heart disease who underwent PCI. The inclusion criteriawere all patients aged ≥ 30 years with a diagnosis of CHD and underwent PCI. Exclusion criteria were all patients who had historyof aortic stenosis, aortic regurgitation, pulmonary hypertension, hypertrophic cardiomyopathy, and kidney disease. The sample wasdrawn with consecutive sampling method. NT-proBNP levels was measured before and 96 hours after PCI. In pre-PCI, NT-proBNPlevels was (909.66 ± 1360.56) pg/mL while ejection fraction was (56.40 ± 11.68) % and in post-PCI, NT-proBNP levels was (791.22± 1234.67) pg/mL while ejection fraction was (61.33 ± 11.09)%. There was a correlation between NT-proBNP levels and ejectionfraction (r = -0.572, p = 0.001), showed that every decrease in the levels of NT-proBNP indicates a change in heart functionassociated with an increase in ejection fraction, and vice versa. In conclusions, there was significant difference neither in NTproBNPlevels nor in ejection fraction. The significant correlation between NT-proBNP levels and ejection fraction can be used forprediction of heart failure post PCI. (FMI 2015;51:16-21)

Keyword :

NT-proBNP, ejection fraction, coronary heart disease, percutaneous coronary intervention, cardiac biomarker,


References :

Antonopoulos AS, Margaritis M, Lee R, Channon K, Antoniades C ,(2012) Statins as anti-inflammatory agents in atherogenesis: molecular mechanisms and lessons from the recent clinical trials 18, 1519–1530 : Curr Pharm Des

Chen Y, Ng Jao YTF, Fang CC, Yu CL, Chen C, Wang SP ,(2004) Recognition of left main occlusion in acute coronary syndrome 20, 139-146 : Acta Cardiol Sin





Archive Article

Cover Media Content

Volume : 51 / No. : 1 / Pub. : 2015-01
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  2. The Metformin And Hyperbaric Oxygen Therapy On The Nuclear Factor Kappa β (nf-κβ) And Fibroblast Growth Factor (fgf) Expression In The Wound Of Hyperglycemic Rats
  3. Bactericidal Effect Of Topical Vitis Vinifera To Methicillin-resistant Staphylococcus Aureus (mrsa) On Rattus Norvegicus Skin Wound
  4. Cardiac Stress Marker Nt-probnp As An Indicator Of Changes In Cardiac Function Post Percutaneous Coronary Intervention
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