UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 2 / Published : 2007-04

Order : 8, and page :105 - 112

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Original Article :

Case report: successful treatment of stevens johnson syndrome-toxic epidermal necrolysis with intravenous immunoglobulin

Author :

  1. Bony Pramono*1
  2. Ariyanto Harsono*2
  1. Department of Child Health
    Airlangga University School of Medicine
    Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Child Health
    Airlangga University School of Medicine
    Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Steven Johnson Syndrome is a serious disease of the skin characterized by triad of erythema exudativum multiforme lesions affecting skin, orifices and eyes. Immunological basis of this disease is hypersensitivity type III and IV. The differential diagnosis are Staphylococcal Scalded Skin Syndrome and Toxic Epidermal Necrolysis. The mainstay of treatment is discontinuation of previously given drugs. Supportive treatment consisting fluid therapy, skincare, symptomatic and antibiotic for existing skin infection. Intravenous Immunoglobulins is used in severe skin involvement and severe complications including eyes. The prognosis is generally good, fatal outcome is usually due to delayed therapy and severe complication.

Keyword :

Steven Johnson Syndrome, Toxic Epidermal Necrolysis, IVIG, prognosis,


References :

S Cheriyon,(1995) The outcome of Stevens-Johnson treated with corticosteroids no info : Allergy Proc

A Freiman,(2005) Dermatologic emergencies no info : CMAJ

PD Ghislain,(2003) Treatment of severe drug reactions: Stevens-Johnson Syndrome Toxic Epidermal Necrolysis and hypersensitivity syndrome no info : Dermatol Online J

JC Roujeau,(2003) Treatment of severe drug reactions: Stevens-Johnson Syndrome Toxic Epidermal Necrolysis and hypersensitivity syndrome no info : Dermatol Online J

RS Gruchalla,(2006) Antibiotic allergy no info : N Engl J Med

M Pirmohamed,(2006) Antibiotic allergy no info : N Engl J Med

KD Gurwitch,(1998) Intravenous immune globulin shortage: Experience at a large childrens hospital no info : Pediatrics

S Hurwitz,(1993) Clinical Pediatric Dermatology A Textbook of Skin Disorders of Childhood and Adolescence Philadelphia : WB Saunders Company

VG Hemming,(1995) Hyperimmune globulins in prevention and treatment of respira



Archive Article

Cover Media Content

Volume : 43 / No. : 2 / Pub. : 2007-04
  1. Detection Of Mycobacterium Leprae Dna In Blood Of The Subclinical Leprosy
  2. Correlation Between Mutant P53 Protein Expression And Histopathological Grading In Astrocytoma Patients
  3. Histopathological Feature Of The Tumor Of Central Nervous System At Airlangga University School Of Medicine, Dr Soetomo Hospital, Surabaya, In 2001-2003
  4. Exercise Diastolic Blood Pressure As An Indicator Of Endothelial Function Among Subjects With Normal And Low Ankle-brachial Index
  5. Effect Of Artificial Unilateral Ureter Total Obstructon On Serum Cystatin-c Levels In Oryctalagus Cuniculus
  6. The Determination Antipyrine On Plasma By Spectrophotometer Ultra Violet-visible
  7. Lumbar Microdiscectomy: Technique, Advantages And Outcomes. Surabaya Experience On 83 Patients
  8. Case Report: Successful Treatment Of Stevens Johnson Syndrome-toxic Epidermal Necrolysis With Intravenous Immunoglobulin
  9. Review Article: Hysterosalpingography As A Diagnostic Test Of Female Infertility
  10. Review Article: Heart Rate Variability. A Remarkable Tool To Assess Sympathovagal Balance
  11. Review Article And Clinical Experience: Hypertension In Diabetic Nephropathy. The Five “satan Circles”, Dha-licoar, The Roles Of Valsartan

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