UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 39 / No. 2 / Published : 2003-04

Order : 6, and page :94 - 101

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Original Article :

Cerebral malaria i. the role of adhesion molecules in its pathogenesis

Author :

  1. Sri Hidajati BS*1
  1. Department of Parasitology, Airlangga University School of Medicine Tropical Disease Center Airlangga University

Abstract :

Cerebral malaria (CM), a complication in Plasmodium falciparum infection, causes high mortality among children in malaria endemic areas, with coma as major clinical symptom. Conventional explanation for the pathogenesis of the coma in CM is obstruction of small blood vessels in the brain by parasitized red blood cells which are sequestered there, that cause inadequate blood supply causing hypoxia and ischemia. Sequestration of parasitized rbc is started with the adherence of p-rbc to the endothelial cells lining blood vessels called cytoadherence, a specific ligand-receptor process involving adhesion molecules expressed on the surface of vascular endothels (i.e. CD 36, thrombospondin, ICAM-1, VCAM-1, E-selectin, Chondroitin-4-sulfate) and molecules on the surface of p-rbc which are related to the infecting parasites (e.g., Pf-EMP-1, Pf-HRP-1), followed or enhanced by rosette formation of normal rbc around p-rbc. Rosetting could involve similar p-rbc molecules involved in cytoadherence and facilitated by several serum proteins. The expression of adhesion molecules on the surface of endothelial cells is stimulated by parasite antigens and up-regulated by cytokines especially TNF- α (and IFN- γ). Efforts have been done to search antibody and medicine that could prevent cytoadherence and/or disrupt rosetting, and to control the production and effects of TNF- α.

Keyword :

cerebral malaria, Plasmodium falciparum, adhesion molecules, sequestration.,


References :

Manson-Bahr PEC and Bell DR,(1987) Malaria and Babesiosis. In : Manson’s Tropical Disease 19th ed. London : Bailliere Tindall

Nauck EG,(1967) Lehrbuch der Tropenkrankheiten 3 Aufl. Stuttgart : George Thieme Verlag





Archive Article

Cover Media Content

Volume : 39 / No. : 2 / Pub. : 2003-04
  1. Editorial Vol 39 No 2 2003
  2. Opinion: Can Or Should Humans Be Cloned?
  3. Correlations Between Psychological Stressor And Severe Preeclampsia (spe)
  4. Post-adenotonsillectomy Monocyte Modulation In Children With Obstructive Chronic Adenotonsillitis
  5. Memory: Where And How Memories Stored?
  6. Cerebral Malaria I. The Role Of Adhesion Molecules In Its Pathogenesis
  7. Reconsideration Of Early Childhood Vaccination (an Epidemiological Study On Relationships Between Vaccination And Autism)
  8. Erythrocyte Sedimentation Rate Determination In Childhood Asthma Due To House Dust Allergy
  9. Comparison Of Mean Tears Examination Results Of Schirmer Test I Using Whatman Paper No. 91 And No. 41 In Normal People
  10. Review Article And Clinical Experience: Pleiotropic Properties Of Statins (potential Benefits Of “peca-gomes” For The Elderly)
  11. Youth Profile In Some Suburban Areas In East Java (preliminary Survey Of The Indonesian Youth Stature At The Fiftieth Anniversary Of Indonesia)
  12. The Role Of Probiotic Containing Formula To The Course Of Diarrhea

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