Folia Medica Indonesiana
ISSN 0303-7932
Vol. 42 / No. 3 / Published : 2006-07
Order : 3, and page :147 - 152
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Original Article :
Changes in the level of acth, cortisol and lymphocyte t count after establishing diagnosis of hiv and aids
Author :
- Nasronudin*1
- Soehartono Taat Putra*2
- Tropical and Infectious Diseases Division, Department of Internal Medicine Airlangga, University School of Medicine
- Pathobiology Division, Department of Pathology, Airlangga University School of Medicine
Abstract :
Ever growing problem relating to HIV is its high morbidity and mortality. PLWAs usually are facing 3 (three) stressors; biological stressor due to HIV intervention, psychological stressor, and psychosocial stressor. ACTH and Cortisol are two interrelating hormones in order to maintain normal level due to various influences including stressful micro environment. Based on those facts, this study require specific approach through psycho-neuro-immunological paradigm to reveal the changes in ACTH and Cortisol level and lymphocyte T count after revealing of HIV and AIDS diagnosis in HIV patients with high risk population without HIV infection. In every subject from both groups we conducted followup for 30 days. We used panel study as our study design, in the same subject we conducted other study at different times. ACTH level in those with HIV infection has tendency to increase on day 7th and day 31st. In negative HIV group, we found dramatic decrease on day 7th and steep increase on day 31st. The increase in ACTH level is still below ACTH level in the first examination. In this study diagnosis of HIV infection is an influence to the increase of hypothalamicpituitary- adrenal (HPA) axis activity. Impact on various body cells, causing changes in ACTH and cortisol level, and lymphocyte count. These changes beside caused by HIV biological stressor, also due to psychological stressor caused in turn by diagnosis revealing, with the latter has a predominant over acute stress.
Keyword :
diagnosis of HIV Infection, ACTH, cortisol, lymphocyte T,
References :
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AA Pilon,(2000) Mechanisms of HIV-associated lymphocyte apoptosis no info : Blood
AD Badley,(2000) Mechanisms of HIV-associated lymphocyte apoptosis no info : Blood
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HH Kampinga,(2002) Molecular chaperones enhance the degradation of expanded polyglutamine retreat androgen receptor in a cellular model of spinal and bulbar muscular atrophy no info : Human Molecular Genetics
Archive Article
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 Volume : 42 / No. : 3 / Pub. : 2006-07 |
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