UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 3 / Published : 2008-07

Order : 8, and page :177 - 183

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Original Article :

Cognitive function disorder as a reflection of immunity status in people living with hiv/aids

Author :

  1. Margarita M Maramis*1
  2. T Arimanto Yuwana*2
  3. Denny Jeffry Rotinsulu*3
  1. Department of Psychiatry Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Psychiatry Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  3. Department of Psychiatry Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

Comorbidity of psychiatric disorder has been linked with HIV (human immunodeficiency virus) since the early epidemics of AIDS (acquired immunodeficiency syndrome), and until recently there have been many literatures focusing on psychiatric problems in relations with HIV seropositive patients (Morrison 2002). Among these patients, 72.3% have psychiatric problems (Cohen et al. 2002). The existing psychiatric problems may exist as dementia, delirium, anxiety, adaptation disorder, depression, substance abuse, and even suicide (Saddock 2003). Data from AIDS treatment house in the United States showed that 65% of the patients had psychiatric disorder other than substance dependency and neurocognitive disorders. If the last two diagnoses are included, the prevalence rate becomes 99.8% (Cohen 1998). In addition, regardless of its correlation with disease progressiveness, the presence of psychiatric disorder may influence life quality, social function, and general health condition of the patients with HIV seropositive (Sherbourne et al 2000). The identification of psychiatric disorders, particularly the disturbance of cognitive function in HIV seropositive patients, becomes important since it has correlation with HIV seropositive progressiveness to become AIDS and to maintain the patients' quality of life. This study examined cognitive function of 34 patients with HIV seropositive in Dr Soetomo Hospital, Surabaya, and correlated it with their immunological status. We found 22 samples in MMSE test who had cognitive disorder (64.7%), and the remaining 12 samples were in normal condition (35.3%). Short memory disorder was found in 19 samples (55.9%) and the other 15 samples were normal (44.1%). The reduction of CD4 immunological status to less than 200 was found 23 respondents (67.6%) and the others had CD4 of more than 200. Significant correlation was found between cognitive function disorder and immunological status of individuals with HIV seropositive (p = 0.021). The cognitive function disorder may reflect immunological status of HIV patients. Therefore, regular testing of cognitive function may be a practical and cost-saving marker of CD4 reduction. Studies using longitudinal design are suggested to find correlation between cognitive function disorder and immunological status with period of cognitive function restoration after receiving ARV. Case-control studies should also be performed to find causal correlation and correlation of each MMSE test items with the decrease of immunity to create a more sensitive measuring tool and to identify early symptoms of cognitive disorder.

Keyword :

cognitive function, immunity status, HIV/AIDS,


References :

Blomenfield & Tiamson,(2003) Acquired Immunodeficiency Syndrome, in Consultation and Liason Psychiatry: A Practical Guide New York : Lippincott & William

Catalan, J,(1999) Psychological problems in people with HIV Infection, in Mental Health and HIV Infection: Psychological and Psychiatric Aspects London : UCL Press





Archive Article

Cover Media Content

Volume : 44 / No. : 3 / Pub. : 2008-07
  1. Effect Of Hsp70 Expression On T-cd4+ Lymphocyte Apoptosis In Hiv/aids Infection
  2. Ifn-γ In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Patients With Pulmonary Tuberculosis Before And After Treatment With Oral Anti-tuberculosis Drugs
  3. Effect Of Cigarette Smoke Exposure On The Expression Of Mutant P53 In Transitional Cells Of The Bladder An Experimental Study On Rattus Norvegicus
  4. Effect Of High Salt (sodium Chloride) Intake On Fracture Risk In Male White Rats (rattus Norvegicus) An Experimental Laboratory Study
  5. Vibrio Cholerae And Its Typing Profile
  6. Change Of Il-1 Concentration And Intracellular Calcium (ca2+ Ic) As An Indicator Of Increased Bitter Taste In Thypoid Fever
  7. Enriching Communication Behavior Change Framework With Religious Element To Increase Compliance In Taking Anti-tuberculous Drugs
  8. Cognitive Function Disorder As A Reflection Of Immunity Status In People Living With Hiv/aids
  9. Lactate Dehydrogenase Level And The Response Of Non Hodgkin Lymphoma Patients To Chemotherapy Cyclophosphamide Doxorubicin, Vincristine, Prednisone (chop) An Observational, Prospective, Cross-sectional Study At The Department Of Internal Medicine, Dr Soetomo Hospital, Surabaya
  10. Fibular Autostrutgraft As The Optional Treatment Of The Femoral Neck Fractures In Surabaya
  11. The Existence Of A Peak In Adolescent’s Height Increments
  12. Review Article And Clinical Experience: Graves’ Disease And Thyroid Storm: Classical And Non-classical (from Formula G/o: P-39.5 – 120 & Bw-score To Formulas Ts-41668 & Cs-7.1.5)
  13. Review Article: The Effects Of Chlamydia Trachomatis Infection On Women’s Reproduction System

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