UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 2 / Published : 2013-04

Order : 3, and page :82 - 87

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Original Article :

Comparing the effect of red yeast rice, date palm, and guava leaf extract on thrombocyte and megakaryocyte count in thrombocytopenic white rats

Author :

  1. Sundari Indah Wiyasihati*1
  2. Kristanti Wanito Wigati*2
  3. Tjitra Wardani*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Thrombocytopenia is an important parameter in Dengue Hemorrhagic Fever (DHF). Herbal therapies have been used by thecommunity to increase the platelet count in DHF cases, i.e. red yeast rice, date palm (Phoenix dactylifera L), and guava leaf extract(Psidium guajava folia). The purpose of this study is to compare the effect of red yeast rice, date palm, and guava leaf extract on theincrease of platelet and bone marrow megakaryocyte count in thrombocytopenic rats. Twenty eight male Wistar rats were dividedinto 4 groups, rendered thrombocytopenia by administering 0.1 ml/100g rat BW/day of heparin by subcutaneous injection for 3 days.K1 was continued with administration of placebo for 3 days (control group), K2 with suspension of 108 mg/kg rat BW/day red yeastrice extract, K3 with date palm extract, and K4 with guava leaf extract. The highest platelet and megakaryocyte count were K2,followed by K3, K4, and K1. MANOVA test showed significant differences (p < 0,05). Based on the LSD test, the red yeast riceextract is the most effective remedy to increase platelet in thrombocytopenic rats. All three extracts showed increasing trend ofmegakaryocyte count but the comparisons are not statistically significant. (FMI 2013;49:82-87)

Keyword :

red yeast rice extract, date palm extract, guava leaf extract, platelet, megakaryocyte,


References :

Kamath JV, Rahul N, Kumar CKA, Lakshmi SM,(2008) Psidium guajava L: a review - : International Journal of Green Pharmacy

Kaushansky K,(2008) Historical review: megakaryopoiesis and thrombopoiesis - : Blood





Archive Article

Cover Media Content

Volume : 49 / No. : 2 / Pub. : 2013-04
  1. The Effectiveness Of Topical Garlic Extract For Methicillin Resistant Staphylococcus Aureus Treatment In Burns
  2. Mycobacterium Tuberculosis Immunoglobulin M (igm) And Immunoglobulin G (igg) Survey In Hiv-infected Donors
  3. Comparing The Effect Of Red Yeast Rice, Date Palm, And Guava Leaf Extract On Thrombocyte And Megakaryocyte Count In Thrombocytopenic White Rats
  4. Maternally Inherited Nucleotide Variation Of Mitochondrial Dna (mtdna) D-loop Region 126 Pb (nt: 34-159 Hvs Ii) In Madurese Individuals
  5. Rapid Culture Method Using Biphasic Media On Bacteriologic Diagnosis To Detect Mycobacterium Tuberculosis For Determining Pulmonary Tuberculosis
  6. Effect Of Carbide And Cacl2 Concentration On Vitamin C Contents Of Banana Kepok
  7. Direct Cloning Of Melanoma Antigen 1 (mage-1) And The E2 Gene Of Hog Cholera Virus (hcv) From The Blunt End Pcr Product Using Pet 101/d-topo
  8. Quantitation Of Microorganisms In Lower Respiratory Tract Secretions
  9. Bmd-qus Assessment Result Appropriates To Diagnose Osteoporosis
  10. Acid-fast Bacteria M. Leprae Examination In Leprosy Patients Before And After Treatment
  11. Diagnostic Role Of Intra Operative Ovarian Cyst Fluid Cytology In Determining Malignancy
  12. Correlation Between Adolescents' Knowledge On Drugs Hazard And Their Behavior In Drug Abuse In Tulungagung
  13. Basal Insulin As Add-on Therapy To Oral Glucose-lowering Drugs In Insulin Naive Patients With Type 2 Diabetes Mellitus In Primary Public Health Center

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