UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 3 / Published : 2013-07

Order : 6, and page :163 - 167

Related with : Scholar   Yahoo!   Bing

Original Article :

Comparison of platelet anti aggregation effect on acute thrombotic stroke with diabetes melitus and non-dibetes melitus

Author :

  1. Adeltrudis Adelsa*1
  2. Siti Sjamsiah*2
  3. Mohammad Saiful Islam*3
  1. Faculty of Pharmacy, Airlangga University
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Kedokteran

Abstract :

Stroke was the highest cause of death and disability of all ages (15.4%) in Indonesia based on RISKESDAS 2007. Thrombotic strokeis one of ischemic stroke that had prevalence of 58.3%. Acetosal/ASA is one of anti-platelet which has been used widely as secondaryprevention for stroke meanwhile, diabetic melitus (DM) was one of the risk factor. Anti-aggregation platelet effect was measured byLight Transmission Aggregometry (LTA). The test had been done twice, before and after ASA usage for 7-10 days. 24 patients thatwere involved, hospitalized for acute thrombotic stroke at least 7-10 days, 15 from non-diabetic group and 9 from diabetic group.The results showed that there is no significant difference in demographic and risk factors for those patients (X2 test, p>0.05). Theaggregation percentage were analyzed statistically by pair t-test for pre-and post-within group, and independent t-test to comparethose two groups. The aggregation percentage of diabetic patients (n=9) was 11-48% (pre) and 7-43% (post). Meanwhile, theaggregation percentage of non-diabetic patients (n=15) was 13-64% (pre) and 13-39% (post). The usage of ASA 1 x 100 mg gave alowering aggregation percentage (t<0,05). For the comparison between diabetic and non-diabetic patients with acute thromboticstroke, there were no difference (p>0,05). It can be concluded that there were no difference on anti-platelet aggregation of ASAbetween diabetic and non diabetic patients with acute thrombotic stroke. For practical purpose, it can be suggested to confirmpercentage aggregation ASA with instrument that applied reliable clinical meaning.(FMI 2013;49:163-167)

Keyword :

acetyl salicylic acid (ASA), diabetic, platelet aggregation, thrombotic, stroke,


References :

Angiolillo DJ,(2009) Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directions - : Diabetes Care

DiChiara J, Bliden KP, Tantry US, Hamed MS, Antonino MJ, Suarez TA, Bailon O, Singla A, Gurbel PA,(2007) The effect of aspirin dosing on patelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) study - : Diabetes





Archive Article

Cover Media Content

Volume : 49 / No. : 3 / Pub. : 2013-07
  1. Pharmacodynamics Study Of Cholecalciferol To Glut4 Protein Translocation In Muscle Fiber Of Hyperglycemia Micewhich Inducted By Streptozotocin
  2. The Comparison Of Simvastatin And Atorvastatin Efficacy In Lowering Lipid Profile And Apolipoprotein-b Of Diabetic Dyslipidemia Patient
  3. Sero-epidemiological Study On Dengue Virus Infection In Four Indonesian Cities
  4. Asymptomatic Malaria In Trenggalek District, East Java Province As Revealed By Microscopic Examination And Single Step Pcr
  5. Correlations Between Nutritional Status Changes With Number Of Cd4 Cell Changes In Hiv/aids Patients
  6. Comparison Of Platelet Anti Aggregation Effect On Acute Thrombotic Stroke With Diabetes Melitus And Non-dibetes Melitus
  7. Analysis Of Antibiotic Use In Vap (ventilator-association Pneumonia) Patients
  8. Differentiation Of Chloroform Etching Time On Acrylic Resin Denture Teeth To Shear Bond Strength With Resin Composite
  9. Profile Of Mdr-tb Patients In Dots Outpatient Clinic, Dr. Soetomo Hospital, Surabaya, From January 2010 To March 2011
  10. The Using Of Arv Pattern To Patients On Hiv/aids In Upipi Dr. Soetomo Hospital, Surabaya, January - June 2011
  11. Pharmaceutical Care And Anti-hypertension Treatment At Trf-ht Patients Undergoing Regular Hemodialysis. A Study At Hemodialysis Room, Dr Haryoto Hospital, Lumajang, East Java, Indonesia
  12. Management Of Antenatal Hydronephrosis. A Report Of 2 Cases

Information index.php/JIPK/FMI