UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 2 / Published : 2006-04

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Original Article :

Comparison of serum estrogen and plasma transforming growth factor Β-1 (tgf Β-1) levels in benign prostatic hyperplasia (bph)–non bph patients over 50 years old and younger (30-40 years old)

Author :

  1. Soetojo*1
  1. Department of Urology Airlangga University School of Medicine Dr Soetomo Teaching Hospital Surabaya

Abstract :

The objective of this study was to compare serum estrogen and plasma transforming growth factor β-1 (TGF β-1) levels in benign prostatic hyperplasia (BPH) – non BPH patients over 50 years old and younger (30-40 years old) in Dr Soetomo Hospital Surabaya. A prospective case control study was conducted on 30 patients with BPH over 50 years old (1st group); non BPH patients over 50 years old (2nd group); and younger, 30-40 years old, (3rd group) from October 2005 to January 2006 in Dr Soetomo Hospital Surabaya. Data were collected from patients attending to the outpatient department and hospitalized patients. We compared serum estrogen and plasma TGF β-1 levels between the 1st and 2nd groups, and between the 2nd and 3rd groups. Thirty patients were included, no significant differences were found in serum estrogen level between the 1st and 2nd groups as well as the 2nd and 3rd groups (p>0.05). There were significant differences in plasma TGF β-1 levels between the 1st and 2nd groups (p0.05). Conclusively, BPH is not only dependent on estrogen and TGF β-1 levels, but other factors such as dietary, genetic, neurotransmitters, and immunologic factors were implicated in the pathogenesis of BPH development. In elderly patients with BPH, there were increased estrogen levels and decreased TGF β-1 levels in circulation.

Keyword :

growth factors, prostatic hyperplasia, aging male, estradiol,


References :

PP Banerjee,(2001) Increased androgen receptor expression correlates with development of age-dependent, lobe spesific spontaneous hyperplasia of the brown norway rat prostate no info : Endocrinology

S Banerjee,(2001) Increased androgen receptor expression correlates with development of age-dependent, lobe spesific spontaneous hyperplasia of the brown norway rat prostate no info : Endocrinology

TR Brown,(2001) Increased androgen receptor expression correlates with development of age-dependent, lobe spesific spontaneous hyperplasia of the brown norway rat prostate no info : Endocrinology

C Chatelain,(2001) Regulation of prostate growth in benign prostatic hyperplasia no info : no info

L Denis,(2001) Regulation of prostate growth in benign prostatic hyperplasia

no info : no info

S Khoury,(2001) Regulation of prostate growth in benign prostatic hyperplasia

no info : no info

J Mc Connell,(2001) Regulation of prostate growth in benign pr



Archive Article

Cover Media Content

Volume : 42 / No. : 2 / Pub. : 2006-04
  1. Balancing Selection Of Hla Class Ii Among Indonesians
  2. The Influence Of Extremely Low Frequency (elf) Magnetic Fields Induction To The Production Of Ifn- γ On Balb/c Mice
  3. Comparison Of Serum Estrogen And Plasma Transforming Growth Factor Β-1 (tgf Β-1) Levels In Benign Prostatic Hyperplasia (bph)–non Bph Patients Over 50 Years Old And Younger (30-40 Years Old)
  4. Role Of Mouthpiece On The Efficacy And Safety Of Budesonide Turbuhaler In The Treatment Of Asthmatic Children: Lesson From M3 Study
  5. The Effect Of Kegel On Management Of Urine Elimination Problems For Elderly A Quasy–experimental Study
  6. Prevalence Of Cataract In Diabetic Patients At Ophthalmology Outpatient Clinic, Dr Soetomo Hospital, Surabaya
  7. The Effects Of Orchidectomy And Detorsion After Unilateral Testicular Torsion Upon Immune Response In The Contralateral Testis
  8. Fecal Material (fm) In Appendiceal Lumen: Acute Or Chronic Inflammation?
  9. The Difference Of The Quality Of Life In The End State Renal Disease Patient Between Continuous Ambulatory Peritoneal Dialysisis And Haemodialysis Therapy
  10. Ocular Complication Of Ethambutol Used For Pulmonary Tuberculosis Therapy In Balai Pengobatan Dan Pemberantasan Penyakit Paru, Surabaya
  11. Review Article And Clinical Experience: Bridging The Gap In The Lipid Management: The Roles Of Hdl-c In The Cves And Creating A New Concepts For Its Raising

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