UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 2 / Published : 2015-04

Order : 10, and page :125 - 131

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Original Article :

Correlation between heat shock protein (hsp) 70 level and left ventricular dysfunction and its effect on cardiovascular and rehospitalization incidence in patients with acute coronary syndrome

Author :

  1. Ni Gusti Putu Sri Andayani*1
  2. Dwi Ariyanti*2
  3. J Nugroho Eko Putranto*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

HSP70 role in coronary artery disease (CAD) is still debated. Some studies showed that it played a role as a danger signal initiatesinflammation response involved in left ventricular (LV) remodeling that result in LV dysfunction and heart failure. Our study aimedto prove the association between extracellular HSP70 level and LV dysfunction and its effect on cardiovascular events andrehospitalization in ACS patients Sixty patients with ACS in Dr. Soetomo Hospital between July and October 2013 were followed upfor 6 months. The patients were stratified into low and high HSP70 group. HSP70 was measured at the initial admission while LVfunction by echocardiography was assessed at the initial admission and compared after 3 months of follow up. Kaplan-Meiersurvival analysis was done to describe heart failure, mortality, and rehospitalization caused by cardiovascular disease during 6months follow-up in both groups. The HSP70 level was significantly correlated with LVEF at admission and after 3 months (r=-0.689; p<0.001; r=-0.705; p<0.001), LV PW MPI at admission and after 3 months (r=0.507; p<0.001; r=0.675; p<0.001), LV TDIMPI at admission and after 3 months (r=0.588; p<0.001; r=0.672; p<0.001), DT at admission (r=-0.322; p=0.012), E/A atadmission (r=0.373; p=0.003), E/E’ at admission and after 3 months (r=324; p=0.011; r=0.382; p=0.006). In our study, higherHSP70 levels were associated with an increased heart failure (log-rank test, p<0.001) during the 6 months follow-up period.Kaplan-Meier survival analysis showed HR of heart failure based on the HSP70 median was 5.35 (CI 95% (2.25-12.7); p<0.001),HR of mortality 3.096 (CI95% (0.838-11.444); p=0.09) and HR of rehospitalization 85.685 (CI 95% (0.059-125012.62); p=0.231).In conclusion, extracellular HSP70 level associated with LV function and heart failure in the patients with ACS. (FMI 2015;51:125-131)

Keyword :

acute coronary syndrome, HSP70, LV function, heart failure, mortality and rehospitalization,


References :

Bielecka-Dabrowa A, Barylski M, Mikhailidis DP, Rysz J, Banach M ,(2009) HSP 70 and atherosclerosis-– protector or activator? 13, 307-317 : Expert Opin Ther Targets

Jenei ZM, Gombos T, Förhécz Z, Pozsonyi Z, Karádi I, Jánoskuti L, Prohászka Z ,(2013) Elevated extracellular HSP70 (HSPA1A) level as an independent prognostic marker of mortality in patients with heart failure 18, 809-813 : Cell Stress Chaperones





Archive Article

Cover Media Content

Volume : 51 / No. : 2 / Pub. : 2015-04
  1. Implementation Of Pharmaceutical Care In Resolving Drug Problems In Type 2 Diabetes Mellitus
  2. Comparison Of The Effect Of Statin Types On The Reduction Of Lipid Profile And Hs-crp Inflammatory Marker In Diabetics With Dyslipidemia
  3. Ciprofloxacin Is Effective In Benign Prostatic Hyperplasia (bph) Patients With Urethral Catheters
  4. Procalcitonin As Biomarker Of Antibiotic Effectivity In Communityacquired Pneumonia
  5. Effect Of Fursultiamine Supplementation On Left Ventricular Ejection Fraction (lvef) In Grade Iii – Iv Heart Failure Patients
  6. Diagnostic Value Of St2 In Patients With Acute Myocardial Infarction
  7. Molecular Analysis Of Rpob Gene Of Mycobacterium Tuberculosis In Patients With Suspected Pulmonary Tuberculosis In Surabaya
  8. Liver Function Tests Of Patients With Dengue Fever, Dengue Hemorrhagic Fever And Dengue Shock Syndrome In Tropic And Infectious Disease Ward In The Department Of Internal Medicine, Dr. Soetomo Hospital, Surabaya
  9. Case Report: Dengue Fever With Perimyocarditis
  10. Correlation Between Heat Shock Protein (hsp) 70 Level And Left Ventricular Dysfunction And Its Effect On Cardiovascular And Rehospitalization Incidence In Patients With Acute Coronary Syndrome
  11. Effect Of Tomato (lycopersicum Commune) Juice On Vaginal Wall Elasticity In Menopausal Rats
  12. Acetosal Resistance In Coronary Artery Disease Between And Within Type 2 Diabetes Mellitus Patients
  13. Immunochromatography Method For Rotavirus Detection Provides Good Accuracy In Diagnosis Of Rotavirus Diarrhea In Children

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