UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 3 / Published : 2009-07

Order : 4, and page :193 - 203

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Original Article :

Correlation between p53 protein expressions in the incidence of metastasis in well-differentiated thyroid cancer

Author :

  1. Yan Efrata Sembiring *1
  2. Sunarto Reksoprawiro *2
  3. Tulus Panuwun*3
  1. Department of Surgery, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya
  2. Department of Surgery, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya
  3. Department of Pathology, Faculty of Medicine, Airlangga University, Dr Soetomo Hospital, Surabaya

Abstract :

Mostly well-differentiated thyroid carcinoma has a good prognosis. Distant metastases are one of bad prognostic factor. Epidemiological studies provided that the mutant protein p53 play a role on thyroid carcinoma oncogenesis. Our objective is to know whether protein p53 expressed in well-differentiated thyroid carcinoma and how is the correlation of the protein p53 expression and the metastases in well-differentiated thyroid carcinoma. Method that use in this study is cross sectional study, clinical data noted from the medical record. Thirty paraffin blocks of thyroid carcinoma patient’s that undergone surgery at Department of Surgery Dr. Soetomo Hospital during January – December 2005, were stained with p53 imunohistochemical. We analyzed the correlation of protein p53 expression and metastases in well-differentiated thyroid carcinoma. From the 30 samples, 28 (93.3%) showed protein p53 expression and 2(6.7%) no protein p53 expression in imunohistochemical staining. There were metastases in 17 patients (57%), 11 patients (36.7%) with lymph node metastases, 4 patients (13.2%) with distant metastases and 2 patients (6.8%) with distant and lymph node metastases. There was a significant correlation between protein p53 expression and occurrence of distant metastases (p = 0.027), stronger expression of protein p53 showed higher occurrence of distant metastases. There was also a correlation between protein p53 expression and the patients ages (p>0.05). There was no correlation between protein p53 expression and extra capsular invasion, tumor size, and lymph node metastases. We concluded that protein p53 expression found in almost well differentiated thyroid carcinoma (93.3%). Therefore, there was a correlation between protein p53 expression and distant metastases in well-differentiated thyroid carcinoma, but no correlation with lymph node metastases.

Keyword :

Protein p53 expression, well-differentiated carcinoma, metastases,


References :

Hodgson NC, Button J.,(2004) Thyroid cancer : Is the incidence still increasing ? - : Ann Surg Oncol

Arja Jukkola, Risto Bloigu, Tapani Ebeling,(2004) Prognostic factors in differentiated thyroid carcinoma and their implications for current staging classifications - : Endocrine Related Cancer





Archive Article

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Volume : 45 / No. : 3 / Pub. : 2009-07
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